从淡竹叶 Chloranthus serratus 的根部分离得到具有神经保护作用的桉烷型倍半萜。
Discovery of eudesmane-type sesquiterpenoids with neuroprotective effects from the roots of Chloranthus serratus.
机构信息
School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
出版信息
Fitoterapia. 2021 Sep;153:104971. doi: 10.1016/j.fitote.2021.104971. Epub 2021 Jun 21.
Seven eudesmane-type sesquiterpenoids, including three pairs of racemic compounds (1a-3a and 1b-3b) and a sesquiterpenoid lactone (4), were obtained from the roots of Chloranthus serratus. The structures of these sesquiterpenoids were characterized based on spectroscopic analyses, ECD calculations, and X-ray diffraction experiment. Neuroprotection assays of the isolated eudesmane-type sesquiterpenoids were conducted on HO damaged PC12 cells. At the concentration of 10 μM, compounds 1b and 4 increased cell viability from 54.8 ± 3.3% to 76.8 ± 2.3 and 72.7 ± 8.2%, respectively.
从金粟兰科植物银线草 Chloranthus serratus 的根部分离得到了 7 个榄烷型倍半萜类化合物，包括 3 对（1a-3a 和 1b-3b）外消旋化合物和 1 个倍半萜内酯（4）。根据光谱分析、ECD 计算和 X 射线衍射实验确定了这些倍半萜的结构。对分离得到的榄烷型倍半萜进行了 HO 诱导损伤的 PC12 细胞神经保护活性测试。在 10 μM 的浓度下，化合物 1b 和 4 可使细胞活力分别从 54.8±3.3%提高到 76.8±2.3%和 72.7±8.2%。
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