Department of Veterinary Surgery, Rajamangala University of Agriculture and Technology, Chon Buri, Thailand.
Department of Pre-clinic and Applied Animal Science, Mahidol University, Nakhon Pathom, Thailand.
J Biomater Appl. 2021 Oct;36(4):701-713. doi: 10.1177/0885328221999227. Epub 2021 Mar 2.
To understand the complication and histopathological characteristics between the Silk Fibroin/Polyurethanes (SF/PU) and the host response, and to unveil the compatibility of the patch in diabetes individuals.
Rats were divided into DM and control (CT) groups, and the DM group was induced with streptozotocin. All groups underwent the SF/PU patch implantation in the abdominal aorta, and the implanted patches were evaluated at one, two, three, and four weeks after implantation.
DM group had more fibrosis formation and a delayed endothelialization compared to the CT group. There was no evidence of chronic inflammation in both DM and CT groups.
Fibrosis in hyperglycemic individuals could promote the formation of new vascular structures in the implanted patch such as endothelial and vascular smooth muscle cells. In summary, the SF/PU patch was no serious complications when implanted under hyperglycemia, and the patch was suitable to implant in diabetes mellitus.
了解丝素/聚醚（SF/PU）与宿主反应之间的并发症和组织病理学特征，并揭示该补片在糖尿病个体中的相容性。
大鼠分为糖尿病（DM）组和对照组（CT），DM 组用链脲佐菌素诱导。所有组均在腹主动脉内植入 SF/PU 补片，植入后 1、2、3、4 周评估植入补片。
与 CT 组相比，DM 组纤维化形成更多，内皮化延迟。DM 组和 CT 组均无慢性炎症证据。
高血糖个体中的纤维化可能促进植入补片中的新血管结构的形成，如内皮细胞和血管平滑肌细胞。总之，在高血糖条件下植入 SF/PU 补片没有严重的并发症，该补片适合植入糖尿病患者。
