Kelsey J E, Landry B A
Department of Psychology, Bates College, Lewiston, Maine 04240.
Behav Neurosci. 1988 Apr;102(2):289-93. doi: 10.1037//0735-7044.102.2.289.
Rats with lesions of the medial septum were more likely to begin swimming in the wrong direction, swim farther, and, therefore, require more time to find a platform hidden in a Morris water tank than were control rats. Although the performance of the rats with medial septal lesions did improve over trials, their asymptotic performance also failed to equal that of the controls. Movement of the platform to a new position in the tank disrupted the performance of both groups, and, again, the rats with medial septal lesions were slower to locate the moved platform. However, this deficit was completely eliminated when a visual cue indicating the location of the moved platform was introduced. We suggest that these data indicate that damage to the septo-hippocampal cholinergic projection system produces a deficit in the formation or utilization of a spatial map (reference memory) that represents the location of a place with respect to the surrounding distal cues.
与对照组大鼠相比，内侧隔区受损的大鼠更有可能一开始就朝着错误的方向游泳，游得更远，因此，在莫里斯水迷宫中找到隐藏平台所需的时间更长。尽管内侧隔区受损的大鼠在多次试验中的表现有所改善，但其最终表现仍不及对照组。将平台移至水迷宫中的新位置会干扰两组大鼠的表现，同样，内侧隔区受损的大鼠找到移动后的平台的速度较慢。然而，当引入一个指示移动后平台位置的视觉线索时，这一缺陷就完全消除了。我们认为，这些数据表明，隔区-海马胆碱能投射系统受损会导致在形成或利用空间地图（参考记忆）方面出现缺陷，该空间地图表示一个地点相对于周围远处线索的位置。
