Törnberg S A, Carstensen J M, Holm L E
Department of General Oncology, Karolinska Sjukhuset, Stockholm, Sweden.
Acta Oncol. 1988;27(1):39-42. doi: 10.3109/02841868809090316.
The relation between serum levels of cholesterol and beta-lipoprotein (BLP) and stomach cancer risk was studied in a Swedish cohort of 92,710 individuals. The cohort was examined with a single measurement of cholesterol and BLP between 1963 and 1965 and followed up in the Swedish Cancer Registry until 1983. During the follow-up period 576 stomach cancers were reported. The risk of stomach cancer was negatively correlated to serum levels of cholesterol with a relative risk (RR) of 0.85 for every 40 mg/dl increase of cholesterol (p less than 0.001) and to BLP with an RR of 0.90 for every 3 units increase of BLP (p less than 0.01) when analysed one at a time. In a multiple regression analysis, however, only the relation to cholesterol remained statistically significant. The risk association seemed to be most pronounced between the third and fifth years of follow-up.
在一个由92710名个体组成的瑞典队列中，研究了血清胆固醇水平和β-脂蛋白（BLP）与胃癌风险之间的关系。该队列在1963年至1965年间进行了一次胆固醇和BLP测量，并在瑞典癌症登记处随访至1983年。随访期间报告了576例胃癌病例。一次分析一个指标时，胃癌风险与血清胆固醇水平呈负相关，胆固醇每增加40mg/dl，相对风险（RR）为0.85（p<0.001）；与BLP也呈负相关，BLP每增加3个单位，RR为0.90（p<0.01）。然而，在多元回归分析中，只有与胆固醇的关系仍具有统计学意义。风险关联似乎在随访的第三年至第五年最为明显。
