Törnberg S A, Holm L E, Carstensen J M
Department of General Oncology, Karolinska Sjukhuset, Stockholm, Sweden.
Acta Oncol. 1988;27(1):31-7. doi: 10.3109/02841868809090315.
The relation between breast cancer risk and serum levels of cholesterol and beta-lipoprotein (BLP), height, weight, Quetelet's index and blood pressure was studied in a cohort of 46,570 Swedish women less than 75 years of age. The cohort was examined between 1963 and 1965 and followed up in the Swedish Cancer Registry until 1983. During this period 1,182 cases of breast cancer were reported. Of those, 196 were reported among women less than 50 years of age. Statistically significant positive associations were observed between height, weight, and systolic blood pressure and breast cancer risk. No clear trend in cancer risk related to serum cholesterol or BLP was seen in the total material. In a stepwise Cox multiple regression analysis only the associations with height and blood pressure remained significant. Among women, having their cancer diagnosed before the age of 50, higher Quetelet's index was associated with a lower cancer risk, whereas a positive correlation was seen among women greater than or equal to 50 years. In the group of younger women a high BLP level was associated with an increased risk of breast cancer. This relation became even stronger when studied in a multivariate analysis, which also showed a negative correlation between serum cholesterol and cancer risk.
在一组46570名年龄小于75岁的瑞典女性中，研究了乳腺癌风险与血清胆固醇和β脂蛋白（BLP）水平、身高、体重、体重指数及血压之间的关系。该队列在1963年至1965年间接受检查，并在瑞典癌症登记处随访至1983年。在此期间，报告了1182例乳腺癌病例。其中，196例报告于年龄小于50岁的女性中。观察到身高、体重和收缩压与乳腺癌风险之间存在统计学显著的正相关。在整个研究资料中，未发现与血清胆固醇或BLP相关的癌症风险有明显趋势。在逐步Cox多元回归分析中，仅与身高和血压的关联仍具有显著性。在50岁之前被诊断出癌症的女性中，较高的体重指数与较低的癌症风险相关，而在年龄大于或等于50岁的女性中则呈正相关。在年轻女性组中，高BLP水平与乳腺癌风险增加相关。在多变量分析中研究时，这种关系变得更强，该分析还显示血清胆固醇与癌症风险之间呈负相关。
