三氯生对儿童过敏性疾病发病机制的影响。

Effect of triclosan on the pathogenesis of allergic diseases among children.

机构信息

Department of Nutrition, China Medical University, No.100, Sec.1, Jingmao Road, Beitun Dist, Taichung, 4046040, Taiwan.

Department of Dietetics, Yunlin Christian Hospital, No.375, Shichang S Road, Xiluo Township, Yunlin, 648102, Taiwan.

出版信息

J Expo Sci Environ Epidemiol. 2022 Jan;32(1):60-68. doi: 10.1038/s41370-021-00304-w. Epub 2021 Mar 2.

DOI:10.1038/s41370-021-00304-w

PMID:33654271

Abstract

BACKGROUND

Few studies have assessed associations between allergic diseases and antibacterial agents in Taiwanese children.

OBJECTIVE

This study aimed to investigate the association of triclosan (TCS) exposure with allergic diseases among preschoolers, disease-specific IgE titers, and a child's sex.

METHODS

Pediatric data were obtained from the Childhood Environment and Allergic Diseases Study (CEAS; 2010) cohort, and their urine and blood samples were used to analyze TCS and IgE concentrations (age 3 group). Three years later, clinical data were obtained again from the age 3 group (age 6 group). Correlations of TCS levels at ages 3 and 6 years with IgE levels and allergic diseases were evaluated.

RESULTS

The TCS levels were higher at age 3 than at age 6 (geometric mean, 1.05 ng/ml vs 0.37 ng/ml). TCS levels were positively correlated with serum IgE levels at ages 3 and 6 years. Asthma and atopic dermatitis were significantly associated with TCS (adjusted OR 1.14, 95% confidence interval [CI] 1.01-1.29; OR 1.22, 95% CI 1.05-1.41). Sex-stratified analysis revealed that TCS levels were positively correlated with IgE levels among boys in the age 6 group and significantly associated with asthma, allergic rhinitis, and atopic dermatitis among boys.

SIGNIFICANCE

TCS exposure is associated with IgE levels and a potentially high risk of pediatric atopic disorders.

摘要

背景

鲜有研究评估过台湾儿童的过敏性疾病与抗菌药物之间的关联。

目的

本研究旨在调查三氯生（TCS）暴露与学龄前儿童过敏性疾病、特定疾病 IgE 滴度以及儿童性别之间的关系。

方法

从儿童环境与过敏性疾病研究（CEAS；2010 年）队列中获取儿科数据，并使用尿液和血液样本分析 TCS 和 IgE 浓度（3 岁组）。3 年后，再次从 3 岁组（6 岁组）获取临床数据。评估 TCS 水平在 3 岁和 6 岁时与 IgE 水平和过敏性疾病的相关性。

结果

3 岁时的 TCS 水平高于 6 岁时（几何均数，1.05ng/ml 比 0.37ng/ml）。TCS 水平与 3 岁和 6 岁时的血清 IgE 水平呈正相关。哮喘和特应性皮炎与 TCS 显著相关（调整后的 OR 1.14，95%置信区间 [CI] 1.01-1.29；OR 1.22，95% CI 1.05-1.41）。性别分层分析显示，6 岁组男孩的 TCS 水平与 IgE 水平呈正相关，且与男孩的哮喘、过敏性鼻炎和特应性皮炎显著相关。