东京地区对羟基苯甲酸酯和三氯生的暴露与过敏性疾病：一项试点横断面研究。
Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study.
作者信息
Mitsui-Iwama Motoko, Yamamoto-Hanada Kiwako, Fukutomi Yuma, Hirota Ryoji, Muto Go, Nakamura Takeshi, Yoshikawa Takahiro, Nakamura Hiroyuki, Mikami Masashi, Morioka Ichiro, Ohya Yukihiro
机构信息
Allergy Center, National Center for Child Health and Development, Tokyo, Japan.
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
出版信息
Asia Pac Allergy. 2019 Jan 21;9(1):e5. doi: 10.5415/apallergy.2019.9.e5. eCollection 2019 Jan.
BACKGROUND
Previous studies have reported that exposure to paraben (Pb) and triclosan (TCS) is associated with allergies. However, Pb and TCS exposure in the Japanese population is not fully understood.
OBJECTIVES
The present study was aimed to examine such exposure among Japanese individuals with allergic diseases.
METHODS
This cross-sectional study included the International Study of Asthma and Allergies in Childhood questionnaire survey to evaluate allergic outcomes and the collection of urine samples to examine Pb and TCS exposure.
RESULTS
Pb containing daily commodities was used in 84.8% children. Pb use was positively associated with current atopic dermatitis (adjusted odds ratio, 4.61; 95% confidence interval, 1.23-17.3). Urinary Pb concentrations were increased significantly in those with current atopic dermatitis (AD) (median, 4.58 vs. 0; < 0.0001), and showed an increased tendency in those with current wheeze (median, 3.45 vs. 1.81; = 0.0535) in participants ≤15 years old. Urinary TCS concentration was under the limit of detection in all children.
CONCLUSION
Urinary levels of Pb were associated with current AD in children. We should pay more attention about Pb and TCS.
背景
既往研究报道，接触对羟基苯甲酸酯（Pb）和三氯生（TCS）与过敏有关。然而，日本人群中Pb和TCS的暴露情况尚未完全明确。
目的
本研究旨在调查日本过敏性疾病患者中的此类暴露情况。
方法
这项横断面研究包括儿童哮喘和过敏国际研究问卷调查以评估过敏结局，以及收集尿液样本以检测Pb和TCS暴露情况。
结果
84.8%的儿童使用含Pb的日常用品。Pb的使用与当前的特应性皮炎呈正相关（校正比值比，4.61；95%置信区间，1.23 - 17.3）。在15岁及以下的参与者中，当前患有特应性皮炎（AD）的人群尿Pb浓度显著升高（中位数，4.58对0；<0.0001），当前有喘息症状的人群尿Pb浓度有升高趋势（中位数，3.45对1.81；P = 0.0535）。所有儿童的尿TCS浓度均低于检测限。
结论
儿童尿Pb水平与当前的AD有关。我们应更加关注Pb和TCS。
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