Awan Nukhbat U, Sohail Shahzada K, Naumeri Fatima, Niazi Shahida, Cheema Khalid, Qamar Samina, Rizvi Syeda Fatima
Ear, Nose, Throat (ENT), King Edward Medical University, Mayo Hospital, Lahore, PAK.
Basic Medical Sciences, College of Medicine, University of Bisha, Bisha, SAU.
Cureus. 2021 Jan 25;13(1):e12911. doi: 10.7759/cureus.12911.
Objective The aim of this study was to determine the association of serum vitamin D and immunoglobulin E (IgE) levels with the severity of allergic rhinitis (AR). Methods This case-control study was conducted at Mayo Hospital, Lahore, from June to September 2020 after obtaining ethical approval. Patients of AR were included and divided with the help of allergic rhinitis and its impact on asthma (ARIA) classification, into group A (cases), patients presenting with moderate to severe symptoms, and into group B (control), patients with mild symptoms, after treatment of AR. The mean difference between serum IgE and serum Vitamin D levels of both groups were compared by t-test. Association was determined by logistic regression and odds ratio. Results A total of 224 patients were included in the study, 112 patients in group A and 112 patients in group B. There were 106 (47.3%) female and 118 (52.7%) male. The mean age of patients in group A was 26.78± 8.92 years and in group B, it was 25.72±8.12 years. Mean serum vitamin D levels in group A were 16.24±6.7 ng/ml and in group B 26.92±35 ng/ml (p=0.0001). Mean serum IgE levels in group A were 383.69±154.86 IU/ml and in group B, they were 373.03±106.83 IU/ml (p=0.0001). Vitamin D deficient patients were 24 times more likely to develop moderate to severe AR disease. Conclusion This study showed that in moderate-severe AR, IgE levels are raised statistically as compared to mild AR and the deficiency of Vitamin D is associated with increasing severity of allergic rhinitis symptoms.
目的 本研究旨在确定血清维生素D和免疫球蛋白E（IgE）水平与过敏性鼻炎（AR）严重程度之间的关联。方法 本病例对照研究于2020年6月至9月在拉合尔梅奥医院进行，研究获得伦理批准。纳入AR患者，并借助过敏性鼻炎及其对哮喘的影响（ARIA）分类，将AR患者分为A组（病例组），即出现中度至重度症状的患者，以及B组（对照组），即经过AR治疗后症状较轻的患者。通过t检验比较两组血清IgE和血清维生素D水平的平均差异。通过逻辑回归和比值比确定关联。结果 本研究共纳入224例患者，A组112例，B组112例。其中女性106例（47.3%），男性118例（52.7%）。A组患者的平均年龄为26.78±8.92岁，B组为25.72±8.12岁。A组血清维生素D平均水平为16.24±6.7 ng/ml，B组为26.92±35 ng/ml（p = 0.0001）。A组血清IgE平均水平为383.69±154.86 IU/ml，B组为373.03±106.83 IU/ml（p = 0.0001）。维生素D缺乏的患者发生中度至重度AR疾病的可能性高24倍。结论 本研究表明，与轻度AR相比，中度至重度AR患者的IgE水平在统计学上有所升高，且维生素D缺乏与过敏性鼻炎症状严重程度增加有关。
