A组链球菌的咽部和皮肤菌株对人皮肤及口腔上皮细胞的黏附作用
Adherence pharyngeal and skin strains of group A streptococci to human skin and oral epithelial cells.
作者信息
Alkan M, Ofek I, Beachey E H
出版信息
Infect Immun. 1977 Nov;18(2):555-7. doi: 10.1128/iai.18.2.555-557.1977.
Abstract
Group A streptococci isolated from skin adhere in greater numbers to human skin epithelial cells than to cells obtained from buccal mucosa whereas streptococci isolated from a throat tend to adhere in greater numbers to buccal epithelial cells than to skin epithelial cells in vitro. M protein-producing strains of group A streptococci did not adhere in significantly greater numbers than M-negative strains. Lipoteichoic acid inhibited binding of streptococci to skin epithelial cells as well as was previously shown for oral epithelial cells. Our results suggest that lipoteichoic acid is more centrally involved than M protein in binding streptococci to skin and mucosal surfaces.
摘要
从皮肤分离出的A组链球菌比从颊黏膜获得的细胞更大量地黏附于人类皮肤上皮细胞，而从咽喉分离出的链球菌在体外往往比皮肤上皮细胞更大量地黏附于颊上皮细胞。产生M蛋白的A组链球菌菌株黏附的数量并不显著多于M阴性菌株。脂磷壁酸抑制链球菌与皮肤上皮细胞的结合，正如之前对口腔上皮细胞所显示的那样。我们的结果表明，在链球菌与皮肤和黏膜表面的结合中，脂磷壁酸比M蛋白更起核心作用。
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