癌症相关乳酸脱氢酶是人类LDH-A（骨骼肌同工酶）的一种酪氨酰磷酸化形式。
Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human LDH-A, skeletal muscle isoenzyme.
作者信息
Li S S, Pan Y E, Sharief F S, Evans M J, Lin M F, Clinton G M, Holbrook J J
机构信息
Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
出版信息
Cancer Invest. 1988;6(1):93-101. doi: 10.3109/07357908809077032.
Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human skeletal muscle isoenzyme, since the partial amino acid sequences of human liver LDH-K/A protein were found to be identical with the known primary structure of human LDH-A isoenzyme and the LDH-A isoenzymes from human placenta and bovine muscle were shown to be tyrosylphosphorylated. This tyrosylphosphorylated LDH-K/A protein was also found to be complexed with 21 kD, 30 kD, and 56 kD proteins.
癌症相关的乳酸脱氢酶是人类骨骼肌同工酶的一种酪氨酸磷酸化形式，因为已发现人类肝脏LDH-K/A蛋白的部分氨基酸序列与人类LDH-A同工酶的已知一级结构相同，并且来自人类胎盘和牛肌肉的LDH-A同工酶被证明是酪氨酸磷酸化的。还发现这种酪氨酸磷酸化的LDH-K/A蛋白与21kD、30kD和56kD的蛋白质复合。
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