State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Chem Soc Rev. 2021 Apr 26;50(8):5243-5280. doi: 10.1039/d0cs00714e.
Characterization of materials at the nanoscale plays a crucial role in in-depth understanding the nature and processes of the substances. Mass spectrometry (MS) has characterization capabilities for nanomaterials (NMs) and nanostructures by offering reliable multi-dimensional information consisting of accurate mass, isotopic, and molecular structural information. In the last decade, MS has emerged as a powerful nano-characterization technique. This review comprehensively summarizes the capabilities of MS in various aspects of nano-characterization that greatly enrich the toolbox of nano research. Compared with other characterization techniques, MS has unique capabilities for real-time monitoring and tracking reaction intermediates and by-products. Moreover, MS has shown application potential in some novel aspects, such as MS imaging of the biodistribution and fate of NMs in animals and humans, stable isotopic tracing of NMs, and risk assessment of NMs, which deserve update and integration into the current knowledge framework of nano-characterization.
纳米尺度材料的特性分析在深入了解物质的本质和过程方面起着至关重要的作用。质谱（MS）通过提供可靠的多维信息，包括准确的质量、同位素和分子结构信息，具有对纳米材料（NMs）和纳米结构进行特性分析的能力。在过去的十年中，MS 已成为一种强大的纳米特性分析技术。本综述全面总结了 MS 在纳米特性分析各个方面的能力，极大地丰富了纳米研究的工具包。与其他特性分析技术相比，MS 具有实时监测和跟踪反应中间体和副产物的独特能力。此外，MS 在一些新的方面显示出应用潜力，例如 MS 对动物和人体内 NMs 的生物分布和命运的成像、NMs 的稳定同位素示踪以及 NMs 的风险评估，这些方面值得更新并整合到当前的纳米特性分析知识框架中。
