Behavioral Sciences Research Center, Life Style Institute, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Trauma Research Center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Adv Exp Med Biol. 2021;1321:287-298. doi: 10.1007/978-3-030-59261-5_26.
The outbreak of the novel coronavirus 2019 (COVID-19) disease has been severe and a cause for major concern around the world. Due to immunological and physiological changes during pregnancy, pregnant women have a higher risk of COVID-19 morbidity and mortality. The aim of this study was to collect and integrate the results of previous studies to get an accurate representation and interpretation of the clinical symptoms, laboratory and radiological findings, and characteristics of pregnant women with COVID-19. We conducted a scientific search in main databases with a combination of related MESH terms and keywords. The outcomes included common clinical symptoms at the time of onset of the disease, common laboratory and radiological findings, the rates of vaginal delivery and Cesarean section, Cesarean section indications, maternal complications, and vertical transmission rates. A total of 51 studies comprising 571 pregnant women with COVID-19 pneumonia were included in the study. The most common symptoms were fever, cough, and dyspnea, respectively. Elevated C-reactive protein and ground-glass opacities were the most common laboratory and radiological findings of COVID-19 pneumonia, respectively. A total of 114 Cesarean sections were performed due to COVID-19-related concerns. There were 55 cases of intubation (11.6%) and 13 maternal deaths (2.3%). The vertical transmission rate was 7.9%. We conclude that the characteristics of pneumonia caused by COVID-19 in pregnant women do not appear to be different from those in the general population with COVID-19 infections. However, pregnant women with underlying diseases were more likely to develop COVID-19 than others, and, in those infected with the virus, the rate of Cesarean delivery and preterm birth increased.
新型冠状病毒 2019（COVID-19）疾病的爆发严重，引起了全球的极大关注。由于怀孕时免疫和生理变化，孕妇患 COVID-19 的发病率和死亡率更高。本研究旨在收集和整合以前研究的结果，以准确地表示和解释患有 COVID-19 的孕妇的临床症状、实验室和影像学发现以及特征。我们在主要数据库中进行了科学搜索，结合了相关的 MESH 术语和关键词。结果包括疾病发病时的常见临床症状、常见的实验室和影像学发现、阴道分娩和剖宫产的比率、剖宫产指征、母体并发症和垂直传播率。共有 51 项研究，包括 571 名患有 COVID-19 肺炎的孕妇，包括在研究中。最常见的症状分别是发热、咳嗽和呼吸困难。升高的 C 反应蛋白和磨玻璃影分别是 COVID-19 肺炎最常见的实验室和影像学发现。由于与 COVID-19 相关的原因，共进行了 114 次剖宫产。有 55 例插管（11.6％）和 13 例产妇死亡（2.3％）。垂直传播率为 7.9％。我们得出结论，COVID-19 在孕妇中引起的肺炎特征似乎与 COVID-19 感染的一般人群没有不同。但是，患有基础疾病的孕妇比其他人更容易感染 COVID-19，而且在感染病毒的孕妇中，剖宫产和早产的比率增加。
