Eye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei.
Department of Ophthalmology, Jiangxi Provincial People's Hospital, Nanchang.
Neuroreport. 2021 Apr 7;32(6):498-506. doi: 10.1097/WNR.0000000000001620.
However, whether the whole-brain functional network hub changes occur in diabetic retinopathy patients remains unknown.
The purpose of the study was to investigate the function network centrality and connectivity changes in diabetic retinopathy patients using the voxel-wise degree centrality method.
Thirty-four diabetic retinopathy patients (18 male and 16 female) and 38 healthy controls (18 male and 20 female) closely matched in age, sex, and education were enrolled in the study. Graph theory-based network analysis was performed to investigate the degree centrality between two groups.
Compared with healthy controls, diabetic retinopathy patients had significantly higher degree centrality values in the pons and bilateral caudate and had significantly lower degree centrality values in the left lingual and right lingual, and right angular/middle occipital gyrus (MOG). Moreover, diabetic retinopathy patients exhibited increased functional connectivity between the bilateral lingual and right cerebellum lobe and right fusiform/bilateral caudate and increased functional connectivity between the right angular/MOG and bilateral anterior cingulum and right cuneus/bilateral precuneus and increased functional connectivity between the bilateral caudate and right lingual and right superior occipital gyrus. In contrast, diabetic retinopathy patients showed decreased functional connectivity between bilateral lingual and left lingual and right lingual and left superior occipital gyrus and decreased functional connectivity between the angular/MOG and right inferior occipital gyrus/right fusiform and left MOG/inferior occipital gyrus and decreased functional connectivity between the bilateral caudate and bilateral cerebellum crus1.
Our results highlight that reorganization of the hierarchy of the cortical connectivity network related to visual network.
然而，糖尿病视网膜病变患者的全脑功能网络枢纽是否发生改变尚不清楚。
本研究旨在使用体素度中心度方法研究糖尿病视网膜病变患者的功能网络中心性和连接性变化。
本研究纳入了 34 例糖尿病视网膜病变患者（18 名男性，16 名女性）和 38 名年龄、性别和教育程度相匹配的健康对照者（18 名男性，20 名女性）。采用基于图论的网络分析方法比较两组之间的度中心度。
与健康对照组相比，糖尿病视网膜病变患者的桥脑和双侧尾状核的度中心度值显著升高，而左侧舌回和右侧舌回、右侧角回/中枕叶的度中心度值显著降低。此外，糖尿病视网膜病变患者双侧舌回与右侧小脑叶、右侧梭状回/双侧尾状核之间的功能连接增加，右侧角回/中扣带回与右侧前扣带回和右侧楔前叶/双侧楔叶之间的功能连接增加，双侧尾状核与右侧舌回和右侧顶叶之间的功能连接增加。相反，糖尿病视网膜病变患者双侧舌回与左侧舌回和右侧舌回与左侧顶叶之间的功能连接减少，角回/中枕叶与右侧下枕叶/右侧梭状回和左侧角回/下枕叶的功能连接减少，双侧尾状核与双侧小脑脚 1 的功能连接减少。
我们的结果强调了与视觉网络相关的皮质连接网络层次结构的重新组织。
