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Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming.

作者信息

Levoux Jennyfer, Prola Alexandre, Lafuste Peggy, Gervais Marianne, Chevallier Nathalie, Koumaiha Zeynab, Kefi Kaouthar, Braud Laura, Schmitt Alain, Yacia Azzedine, Schirmann Aurélie, Hersant Barbara, Sid-Ahmed Mounia, Ben Larbi Sabrina, Komrskova Katerina, Rohlena Jakub, Relaix Frederic, Neuzil Jiri, Rodriguez Anne-Marie

出版信息

Cell Metab. 2021 Mar 2;33(3):688-690. doi: 10.1016/j.cmet.2021.02.003.

DOI:10.1016/j.cmet.2021.02.003
PMID:33657394
Abstract
摘要

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Platelet-rich plasma may accelerate diabetic wound healing by modulating epithelial/endothelial-mesenchymal transition through inhibiting reactive oxygen species-mediated oxidative stress.富含血小板血浆可能通过抑制活性氧介导的氧化应激来调节上皮/内皮-间充质转化,从而加速糖尿病伤口愈合。
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In Vivo Reprogramming of Tissue-Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering.
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Megakaryocytes transfer mitochondria to bone marrow mesenchymal stromal cells to lower platelet activation.巨核细胞将线粒体转移至骨髓间充质基质细胞以降低血小板活化。
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