Zhang Yuelong, Zhuang Huangming, Ren Xunshan, Jiang Fuze, Zhou Panghu
Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.
Front Cell Dev Biol. 2023 Aug 10;11:1246504. doi: 10.3389/fcell.2023.1246504. eCollection 2023.
Osteoarthritis (OA) is a common and disabling disease. For advanced OA, surgical treatment is still the main treatment. Human umbilical cord mesenchymal stem cells (hUC-MSCs) are self-regenerative pluripotent cells, that coordinate cartilage regeneration by secreting various trophic factors, which adjust the injured tissue environment. hUC-MSCs secret extracellular vesicles and participates in OA treatment by transmitting bioactive molecules related to migration, proliferation, apoptosis, inflammatory reaction, extracellular matrix synthesis and cartilage repair. In addition, the combination of multiple substances represented by cartilage matrix and hUC-MSCs also have a significant synergistic effect on OA treatment. Because hUC-MSCs have shown considerable promise in cartilage repair, some scholars have proposed transplanting mesenchymal stem cells into damaged cartilage to delay OA progression. This article reviews the application of hUC-MSCs as a treatment for OA. With the continuous development of routine clinical applications, more reliable intervention modalities for hUC-MSCs in OA treatment will be discovered for the time to come.
骨关节炎（OA）是一种常见的致残性疾病。对于晚期OA，手术治疗仍是主要治疗方法。人脐带间充质干细胞（hUC-MSCs）是自我再生的多能细胞，通过分泌各种营养因子来协调软骨再生，这些营养因子可调节受损组织环境。hUC-MSCs分泌细胞外囊泡，并通过传递与迁移、增殖、凋亡、炎症反应、细胞外基质合成和软骨修复相关的生物活性分子参与OA治疗。此外，以软骨基质为代表的多种物质与hUC-MSCs的组合对OA治疗也具有显著的协同作用。由于hUC-MSCs在软骨修复方面已显示出相当大的前景，一些学者提出将间充质干细胞移植到受损软骨中以延缓OA进展。本文综述了hUC-MSCs作为OA治疗方法的应用。随着常规临床应用的不断发展，未来将发现hUC-MSCs在OA治疗中更可靠的干预方式。
