School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Nat Prod Res. 2022 Jul;36(14):3638-3643. doi: 10.1080/14786419.2021.1875465. Epub 2021 Mar 3.
Three undescribed sesquineolignans, Ziziphusmps A-C () were isolated from the seeds of . their gross structure was identified by comprehensive spectroscopic analyses. The part relative configurations were determined by the NOESY correlation and coupling constant. All isolates were tested for their cytotoxicity against the hepatocellular carcinoma Hep3B and HepG2 cells. The results indicated that none of them exhibited obvious cytotoxicity against two hepatocellular carcinoma cell lines.
从酸枣仁中分离得到了三种新的倍半木脂素，即 Ziziphusmps A-C ()。通过综合光谱分析确定了它们的大致结构。利用 NOESY 相关和耦合常数确定了它们的相对构型。所有分离物均进行了对肝癌 Hep3B 和 HepG2 细胞的细胞毒性测试。结果表明，它们对两种肝癌细胞系均没有明显的细胞毒性。
