China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, PO Box 71, Bundoora 3083, Australia.
China-Australia International Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, PO Box 71, Bundoora 3083, Australia; Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, 111 Dade Road, Yuexiu District, Guangzhou 510120, PR China.
Phytomedicine. 2017 Oct 15;34:38-43. doi: 10.1016/j.phymed.2017.07.004. Epub 2017 Jul 4.
In Chinese medicine, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou is widely used for the treatment of insomnia.
PURPOSE/SECTIONS: This paper summarises the chemistry, psychopharmacology, and compares the pharmaceutical effects of the seeds of Ziziphus jujuba plant, Ziziphus spinosa (ZS) seeds, with benzodiazepines. Whole extracts and constituent compounds have been evaluated in preclinical and clinical studies.
ZS secondary metabolites modulate GABAergic activity and the serotonergic system. The actual therapeutic agents require further confirmation/identification so that new insomnia phytomedicines can be discovered.
在中国医学中，酸枣仁（Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou）被广泛用于治疗失眠。
目的/部分：本文总结了酸枣仁的化学、精神药理学，并比较了枣属植物种子（Ziziphus jujuba 植物的种子，Ziziphus spinosa (ZS) 种子）与苯二氮䓬类药物的药效。在临床前和临床研究中评估了全提取物和成分化合物。
ZS 次生代谢物调节 GABA 能活性和 5-羟色胺能系统。实际的治疗剂需要进一步确认/鉴定，以便发现新的失眠植物药。
