Department of Ophthalmology, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
Department of Ophthalmology, UC Davis, Sacramento, California, USA.
Orbit. 2022 Aug;41(4):509-513. doi: 10.1080/01676830.2021.1894583. Epub 2021 Mar 3.
Mantle cell lymphoma is a rare malignancy to present in the orbit, comprising only 1-5% adnexal lymphomas. Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is an equally uncommon adnexal tumor of sweat gland origin that may present on the eyelid. Herein we present a case of a 77-year old man with no previous cancer history who presented with painless progressive left globe proptosis and an enlarging left upper lid margin lesion, ultimately determined upon biopsy to be simultaneous orbital mantle cell lymphoma with systemic involvement and isolated eyelid EMPSGC. The pathogenesis, clinical manifestation, and management for each rare disease entity are reviewed and concept of collision tumors is discussed.
套细胞淋巴瘤是一种罕见的眼眶恶性肿瘤，仅占附属器淋巴瘤的 1-5%。分泌黏液的汗腺癌（EMPSGC）是一种同样罕见的来源于汗腺的附属器肿瘤，也可能发生在眼睑。本文报道了 1 例 77 岁男性，无既往癌症病史，表现为无痛性进行性左眼眼球突出和左上睑缘增大的病变，最终经活检确定为同时累及眼眶的套细胞淋巴瘤伴全身受累和孤立性眼睑 EMPSGC。对这两种罕见疾病的发病机制、临床表现和治疗进行了回顾，并讨论了碰撞肿瘤的概念。
