Nikzad Mahsa, Banafshe Hamid Reza, Momen-Heravi Mansooreh, Haddad Kashani Hamed, Shiehmorteza Maryam
Department of Clinical Pharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Clin Mol Allergy. 2021 Mar 3;19(1):1. doi: 10.1186/s12948-021-00140-1.
Community acquired pneumonia (CAP) is a prevalent low respiratory infection. Diagnosis is based on clinical symptoms, radiologic evidence and culture. Biomarkers such as IL6, CRP and procalcitonin are helpful in diagnosis. Procalcitonin is a soluble biomarker in serum that increase in systemic inflammation and bacterial infections. People with normal procalcitonin have low risk to infect pneumonia. Patient with CAP have more oxidative stress than normal people. Studies show that receiving vitamin C can reduce incidence of pneumonia. The present study was designed to evaluate the effect of vitamin C supplement on procalcitonin biomarker in patient with CAP.
Patients with CAP who passed inclusion and exclusion criteria after obtaining informed consent, were assigned randomly in two groups of drug and placebo. The drug group received vitamin C (1000 mg/d) daily and medications that physician prescribed for treating CAP for 10 days and placebo group received placebo and medications that physician prescribed. The serum level of procalcitonin was measured at the beginning of the study and after 10 days of intervention.
35 patients finished the study. Serum level of procalcitonin on the first and tenth day did not show any significant difference between drug and placebo groups.
To clarify the relationship between the effects of vitamin C on procalcitonin in CAP, a larger sample size is required.
社区获得性肺炎（CAP）是一种常见的下呼吸道感染。诊断基于临床症状、影像学证据和培养结果。白细胞介素6、C反应蛋白和降钙素原等生物标志物有助于诊断。降钙素原是血清中的一种可溶性生物标志物，在全身炎症和细菌感染时会升高。降钙素原正常的人感染肺炎的风险较低。CAP患者比正常人有更多的氧化应激。研究表明，补充维生素C可降低肺炎的发病率。本研究旨在评估补充维生素C对CAP患者降钙素原生物标志物的影响。
符合纳入和排除标准并获得知情同意的CAP患者被随机分为药物组和安慰剂组。药物组每天接受维生素C（1000毫克/天）及医生开具的治疗CAP的药物，共10天，安慰剂组接受安慰剂及医生开具的药物。在研究开始时和干预10天后测量血清降钙素原水平。
35名患者完成了研究。药物组和安慰剂组在第一天和第十天的血清降钙素原水平没有显示出任何显著差异。
为了阐明维生素C对CAP患者降钙素原的影响之间的关系，需要更大的样本量。
