Berardesca E, Maibach H I
Department of Dermatology, University of California Medical School, San Francisco 94143.
Contact Dermatitis. 1988 Feb;18(2):65-70. doi: 10.1111/j.1600-0536.1988.tb02741.x.
The different reactivity of black and white skin after exposure to sodium lauryl sulphate (SLS) has been investigated. 9 white and 10 black male volunteers entered the study. The tests were performed on the back at 3 sites: untreated skin, skin pre-treated with occlusion and skin pre-delipidized. Irritant reactions were elicited applying 0.5% and 2.0% SLS via Finn chamber patch tests and monitored by means of laser Doppler velocimetry (LDV), transepidermal water loss (TEWL) and stratum corneum water content (WC). Higher TEWL, LDV, and WC values were recorded for 2.0% SLS when compared to 0.5% SLS and baselines. Pre-treatment with short-term occlusion generally increased values, while delipidization produced flattening of the data more detectable in whites than in blacks. Significant TEWL differences for the two concentrations were recorded in whites for the occluded site (P less than 0.02) while in blacks in the untreated (P less than 0.04) and delipidized (P less than 0.03) sites. LDV revealed significant changes in the untreated and pre-occluded white skin (P less than 0.05 and 0.01, respectively). In blacks, the values were significantly different only in the pre-occluded skin (P less than 0.01). Water content correlated with the visual score and was greatly increased in sites with strongly positive reactions (P less than 0.01). It appears that there are significant differences in the modulation of irritation, in the behavior of water barrier function and of the erythematous response between blacks and whites. Clinical correlations are discussed.
研究了黑皮肤和白皮肤在接触月桂醇硫酸酯钠（SLS）后的不同反应性。9名白种男性和10名黑种男性志愿者参与了该研究。测试在背部的3个部位进行：未处理的皮肤、预先进行封闭处理的皮肤和预先脱脂的皮肤。通过Finn室斑贴试验施加0.5%和2.0%的SLS引发刺激反应，并通过激光多普勒测速仪（LDV）、经表皮水分流失（TEWL）和角质层含水量（WC）进行监测。与0.5%的SLS和基线相比，2.0%的SLS记录到更高的TEWL、LDV和WC值。短期封闭预处理通常会使数值增加，而脱脂处理使数据趋于平缓，在白种人中比在黑种人中更明显。在白种人中，封闭部位两种浓度的TEWL存在显著差异（P<0.02），而在黑种人中，未处理部位（P<0.04）和脱脂部位（P<0.03）存在显著差异。LDV显示未处理和预先封闭的白种人皮肤有显著变化（分别为P<0.05和0.01）。在黑种人中，仅在预先封闭的皮肤中数值有显著差异（P<0.01）。含水量与视觉评分相关，在反应强烈为阳性的部位显著增加（P<0.01）。白种人和黑种人在刺激调节、水屏障功能行为和红斑反应方面似乎存在显著差异。讨论了临床相关性。
