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尼日利亚三角州从人和动物源分离出的肠道细菌中质粒介导的氟喹诺酮耐药基因的出现情况。

Occurrence of plasmid mediated fluoroquinolone resistance genes amongst enteric bacteria isolated from human and animal sources in Delta State, Nigeria.

作者信息

Ayobola Ehwarieme Daniel, Oscar Whiliki Onoriadjeren, Ejovwokoghene Ejukonemu Francis

机构信息

Department of Microbiology, Faculty of Science, Delta State University, Abraka, Nigeria.

Department of Science Laboratory Technology, Delta State Polytechnic, Otefe-Oghara, Nigeria.

出版信息

AIMS Microbiol. 2021 Feb 3;7(1):75-95. doi: 10.3934/microbiol.2021006. eCollection 2021.

DOI:10.3934/microbiol.2021006
PMID:33659770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7921378/
Abstract

Plasmid mediated quinolone resistance (PMQR) is a public health challenge arising among other things, from indiscriminate use of the floroquinolones (FQr) prophylactically in animal husbandry. This study examines the occurrence of PMQR genes amongst enteric bacteria isolated from human and animal sources. A total of 720 (360 stool and 360 fish pond water/poultry litter) samples were examined for fluoroquinolone resistant (FQr) bacteria. Percentage FQr was generally higher among human isolates than isolates from animals. Proportion of PMQR amongst FQr isolates were (1.05 and 4.32) % for . from human and animal sources. For spp., spp., spp. and spp., percentages PMQR were 0.00 & 6.93, 0.00 & 6.38, 4.26 & 5.26 and 0.00 &3.03 for human and animal sources respectively, for the isolates. The PMQR genes: A, B, S and A were 11, 15, 7 and 1 amongst a total of 1018 FQr and 29 PMQR isolates respectively. The aac (6')-Ib-cr gene was not detected in this study. Approximate Plasmid bands of PCR amplicon for A, B, S and A respectively were established. The proportion of PMQR genes especially among isolates from animal sources is of public health concern due to the higher possibility of a horizontal FQ resistance transfer to humans.

摘要

质粒介导的喹诺酮耐药性（PMQR）是一个公共卫生挑战，部分原因是在畜牧业中预防性地滥用氟喹诺酮类药物（FQr）。本研究调查了从人和动物源分离的肠道细菌中PMQR基因的出现情况。共检测了720份样本（360份粪便样本以及360份鱼塘水/家禽粪便样本）中的耐氟喹诺酮细菌。人类分离株中的耐氟喹诺酮细菌百分比通常高于动物分离株。人和动物源的耐氟喹诺酮分离株中PMQR的比例分别为1.05%和4.32%。对于大肠杆菌属、克雷伯菌属、肠杆菌属和沙门氏菌属，人和动物源分离株的PMQR百分比分别为0.00%和6.93%、0.00%和6.38%、4.26%和5.26%、0.00%和3.03%。在总共1018株耐氟喹诺酮分离株和29株PMQR分离株中，PMQR基因qnrA、qnrB、qnrS和qepA分别有11个、15个、7个和1个。本研究未检测到aac(6')-Ib-cr基因。分别确定了qnrA、qnrB、qnrS和qepA的PCR扩增子的近似质粒条带。由于氟喹诺酮耐药性水平转移至人类的可能性较高，PMQR基因的比例，尤其是动物源分离株中的比例，引起了公共卫生方面的关注。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b5/7921378/bdc57073c5dd/microbiol-07-01-006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b5/7921378/72a408f60b7a/microbiol-07-01-006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b5/7921378/c5072e2439f5/microbiol-07-01-006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b5/7921378/bdc57073c5dd/microbiol-07-01-006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b5/7921378/72a408f60b7a/microbiol-07-01-006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b5/7921378/c5072e2439f5/microbiol-07-01-006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b5/7921378/bdc57073c5dd/microbiol-07-01-006-g003.jpg

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2
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Medchemcomm. 2019 Jun 28;10(10):1719-1739. doi: 10.1039/c9md00120d. eCollection 2019 Oct 1.
3
Enumerating the economic cost of antimicrobial resistance per antibiotic consumed to inform the evaluation of interventions affecting their use.按抗生素使用量计算抗生素耐药性的经济成本，以用于评估影响抗生素使用的干预措施。
Phylogenetic analysis, biofilm formation, antimicrobial resistance and relationship between these characteristics in Uropathogenic Escherichia coli.
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Mol Biol Rep. 2024 Feb 23;51(1):327. doi: 10.1007/s11033-023-09031-x.
4
Determination of antibiotic resistance patterns and genotypes of Escherichia coli isolated from wild birds.从野生鸟类中分离的大肠杆菌的抗生素耐药模式和基因型的测定。
Microbiome. 2024 Jan 8;12(1):8. doi: 10.1186/s40168-023-01729-1.
5
Virulence, Antibiotic Resistance, and Phylogenetic Relationships of spp. Carried by Migratory Birds in China.中国候鸟携带的[具体物种名称]的毒力、抗生素抗性及系统发育关系
Microorganisms. 2022 Dec 20;11(1):7. doi: 10.3390/microorganisms11010007.
6
Bacterial infections epidemiology and factors associated with multidrug resistance in the northern region of Ghana.加纳北部地区细菌感染的流行病学和与多药耐药相关的因素。
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7
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4
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5
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6
Antimicrobial resistance in humans, livestock and the wider environment.人类、牲畜及更广泛环境中的抗菌素耐药性。
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 5;370(1670):20140083. doi: 10.1098/rstb.2014.0083.
7
Plasmid-mediated quinolone resistance.质粒介导的喹诺酮耐药性。
Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.PLAS-0006-2013.
8
Microbiological effects of sublethal levels of antibiotics.亚致死浓度抗生素的微生物效应。
Nat Rev Microbiol. 2014 Jul;12(7):465-78. doi: 10.1038/nrmicro3270. Epub 2014 May 27.
9
Prevalence and characterisation of plasmid-mediated quinolone resistance and mutations in the gyrase and topoisomerase IV genes among Shigella isolates from Henan, China, between 2001 and 2008.2001 年至 2008 年间中国河南地区志贺菌分离株中质粒介导的喹诺酮耐药性的流行情况及其拓扑异构酶和回旋酶基因突变特征。
Int J Antimicrob Agents. 2013 Aug;42(2):173-7. doi: 10.1016/j.ijantimicag.2013.04.026. Epub 2013 Jun 21.
10
Plasmid-mediated quinolone resistance--current knowledge and future perspectives.质粒介导的喹诺酮耐药性——当前认知与未来展望
J Int Med Res. 2013 Feb;41(1):20-30. doi: 10.1177/0300060513475965. Epub 2013 Jan 23.