Suzuki Kayoko, Matsunaga Kayoko, Ito Akiko, Yagami Akiko, Ito Takashi, Miyazawa Hitoshi, Sugiura Mariko, Adachi Atsuko, Kubota Yumiko, Watanabe Yuko, Kato Atsuko, Nishioka Kazue, Fukunaga Atsushi, Mochizuki Masako, Ikezawa Yuko, Tsunoda Takahiko, Takayama Kaoru, Washizaki Kumiko, Yokozeki Hiroo, Ishihara Takuma, Asada Hideo, Kanto Hiromi
Department of Allergology, Fujita Health University School of Medicine, Nagoya, Japan.
Japanese Contact Dermatitis Research Group, Nagoya, Japan.
Contact Dermatitis. 2021 Mar 3. doi: 10.1111/cod.13827.
There is controversy over late and long-lasting reactions to gold sodium thiosulfate (GST).
To study the GST patch-test reaction by observing the application site after 1 month, and to clarify the relevance of GST sensitization by piercings and dental metals.
A retrospective analysis was performed on 746 patients (143 male; 603 female) who were patch tested using GST of the TRUE Test. We conducted a questionnaire on the presence of piercings or dental metals in these patients.
The GST positive rate was 27.9% at day (D)3 and/or D7 and 40.3% up to the 1-month reading. The positive rate was significantly higher in female patients and increased with age. Sixty-two percent of cases with a positive reaction at D7 continued to show a positive reaction after 1 month. Eleven percent of cases with a negative reaction at D3 and D7 showed a late reaction. Both piercings and dental metals were related to gold sensitization.
The GST of the TRUE Test had a high positive and low false-negative rate. The 1-month reading after the patch test was important for identifying late reactions. Piercing history and dental metal were associated with gold sensitization.
对于硫代硫酸钠金（GST）的迟发性和持续性反应存在争议。
通过观察1个月后的贴敷部位来研究GST斑贴试验反应，并阐明穿刺和牙科金属与GST致敏的相关性。
对746例使用TRUE Test的GST进行斑贴试验的患者（143例男性；603例女性）进行回顾性分析。我们对这些患者是否存在穿刺或牙科金属进行了问卷调查。
在第3天（D）和/或第7天，GST阳性率为27.9%，至1个月读数时为40.3%。女性患者的阳性率显著更高，且随年龄增加。在第7天呈阳性反应的病例中，62%在1个月后仍呈阳性反应。在第3天和第7天呈阴性反应的病例中有11%出现迟发性反应。穿刺和牙科金属均与金致敏有关。
TRUE Test的GST具有高阳性率和低假阴性率。斑贴试验后1个月的读数对于识别迟发性反应很重要。穿刺史和牙科金属与金致敏有关。
