Stewart M, Savage J M, Bell B, McCord B
Nuffield Department of Child Health, Queen's University of Belfast, UK.
Eur J Pediatr. 1988 Feb;147(2):113-5. doi: 10.1007/BF00442205.
All 270 patients presenting with Henoch-Schönlein Purpura over a 13-year period from a total childhood population of 155,000 were studied. This is an incidence of 13.5/100,000 children per year. Fifty-five (20%) were found to have initial evidence of renal involvement, and were re-examined at a mean of 8.3 years later. The 37 with isolated haematuria or haematuria with mild proteinuria (67%) recovered completely. Eighteen (33%) had nephritic or combined nephritic/nephrotic features, of these one died in the acute phase of the illness, only three others have persistent urinary abnormalities but have no biochemical evidence of renal impairment and only minor histological changes. The overall prognosis in this unselected population is therefore good with a mortality less than 1% overall and low long term morbidity of 1.1%. This study indicates a more optimistic outcome in this condition than the majority of published estimates based on more selected groups of patients.
在13年期间，对来自总计155,000名儿童的人群中出现的270例过敏性紫癜患者进行了研究。这相当于每年每100,000名儿童中有13.5例发病。发现55例（20%）最初有肾脏受累的证据，并在平均8.3年后进行了复查。37例单纯血尿或血尿伴轻度蛋白尿的患者（67%）完全康复。18例（33%）有肾炎或肾炎/肾病综合征合并特征，其中1例在疾病急性期死亡，另外只有3例有持续性尿液异常，但无肾功能损害的生化证据，且只有轻微的组织学改变。因此，在这个未经过筛选的人群中，总体预后良好，总体死亡率低于1%，长期发病率低至1.1%。这项研究表明，与大多数基于更多选定患者群体的已发表估计相比，这种疾病的预后更为乐观。
