Maeta H, Vidyasagar D, Raju T, Bhat R, Matsuda H
Department of Pediatrics, University of Illinois, Chicago 60612.
Eur J Pediatr. 1988 Feb;147(2):162-7. doi: 10.1007/BF00442215.
The responses of Surfactant TA instillation in two groups of premature lambs (Group I, 124.8 +/- 1.1 days and Group II, 132.2 +/- 1.2 days, mean +/- SD) and one group of premature baboons (140 +/- 1.6 days) were compared to study the effectiveness of the same surfactant in different animal models. The treatment group received Surfactant TA 100 mg/kg surfactant lipid at 1 to 2 h of age. Control lambs and baboons did not receive surfactant. Sequential measurements of arterial blood gas tension, acid base status, mean airway pressure (MAP) and oxygen requirement (FiO2) were carried out for 8 h after surfactant instillation. The results show that the Group I surfactant-treated lambs improved significantly following instillation. The a/APO2 improved from 0.08 +/- 0.02 before treatment to 0.31 +/- 0.12, and the MAP decreased from 15.8 +/- 0.9 cm H2O to 13.3 +/- 1.3 cm H2O 2.5 h after treatment. At 5.5 h after treatment, the lambs given surfactant deteriorated. Group II treated lambs showed sustained improvement throughout the study period, and improvement in the treated group was not significantly different from Group II control lambs. The surfactant-treated baboons, however, showed sustained and significant improvement in a/APO2 from the time of instillation to the end of the study. These data suggest that the differences in response to the same surfactant therapy between the lamb and baboon models were due to related differences in species, lung maturation, and the differences in response to surfactant, i.e., alveolar leak of protein.
比较了两组早产羔羊（第一组，124.8±1.1天；第二组，132.2±1.2天，均值±标准差）和一组早产狒狒（140±1.6天）中表面活性剂TA滴注的反应，以研究同一表面活性剂在不同动物模型中的有效性。治疗组在出生后1至2小时接受100mg/kg表面活性剂脂质的表面活性剂TA。对照羔羊和狒狒未接受表面活性剂。在滴注表面活性剂后8小时，连续测量动脉血气张力、酸碱状态、平均气道压（MAP）和氧需求（FiO2）。结果显示，第一组经表面活性剂治疗的羔羊在滴注后有显著改善。a/APO2从治疗前的0.08±0.02提高到0.31±0.12，治疗后2.5小时MAP从15.8±0.9cm H2O降至13.3±1.3cm H2O。治疗后5.5小时，给予表面活性剂的羔羊情况恶化。第二组经治疗的羔羊在整个研究期间持续改善，且治疗组的改善与第二组对照羔羊无显著差异。然而，经表面活性剂治疗的狒狒从滴注时到研究结束，a/APO2持续且显著改善。这些数据表明，羔羊和狒狒模型对同一表面活性剂治疗反应的差异是由于物种、肺成熟度的相关差异以及对表面活性剂反应的差异，即蛋白质的肺泡渗漏。
