State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, People's Republic of China.
Institute of Molecular Sciences and Engineering, Shandong University, Qingdao 266237, People's Republic of China.
J Control Release. 2021 Apr 10;332:269-284. doi: 10.1016/j.jconrel.2021.02.030. Epub 2021 Mar 1.
Nano-biotechnologies which combine diagnosis with therapy in an integrated nanoplatform provide a promising prospect for cancer theranostics. Currently, the development of personalized medicine requires the exploitation of "smart" theranostic nanoplatforms with specific targeting, precise cargoes release, non-invasive therapeutics for cancers and so on. High levels of hydrogen peroxide (HO) and glutathione (GSH) are prominent features of tumor microenvironment (TME), which are distinctly different from healthy tissues. Accordingly, extensive redox-responsive theranostic nanoplatforms have been exploited by modulating intracellular redox homeostasis. In this review, we first summarized the recent advances of overexpressed HO- and antioxidant GSH-responsive nanoplatforms for tumor diagnose and treatment. Then, the strategies by synergistically boosting reactive oxygen species (ROS) production and GSH depletion for amplifying oxidative stress are highlighted. At last, the prospects and controversies of stimuli-driven nanotheranostics are also discussed for future development.
纳米生物技术将诊断与治疗整合在一个纳米平台中，为癌症的治疗诊断提供了有前景的前景。目前，个性化医疗的发展需要开发具有特定靶向性、精确药物释放、非侵入性治疗癌症等特点的“智能”治疗诊断纳米平台。高浓度的过氧化氢（HO）和谷胱甘肽（GSH）是肿瘤微环境（TME）的显著特征，与健康组织明显不同。因此，通过调节细胞内氧化还原平衡，已经开发出了大量的氧化还原响应治疗诊断纳米平台。在本文中，我们首先总结了近年来用于肿瘤诊断和治疗的过表达 HO 和抗氧化 GSH 响应纳米平台的最新进展。然后，重点介绍了协同增强活性氧（ROS）生成和 GSH 耗竭以放大氧化应激的策略。最后，还讨论了刺激驱动的纳米治疗诊断的前景和争议，以促进其未来发展。
