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经颅直流电刺激对注意缺陷多动障碍(ADHD)儿童和青少年注意力和抑制控制的影响:一项随机、假刺激对照、三盲、交叉试验的研究方案。

The effects of transcranial direct current stimulation on attention and inhibitory control of children and adolescents with attention-deficit/hyperactivity disorder (ADHD): Study protocol for a randomized, sham-controlled, triple-blind, cross-over trial.

机构信息

Postgraduate Program in Medicine and Health, Medical School of Bahia.

Laboratory of Neuropsychopharmacology, Psychiatry Division of the Professor Edgard Santos University Hospital.

出版信息

Medicine (Baltimore). 2021 Feb 26;100(8):e24283. doi: 10.1097/MD.0000000000024283.

DOI:10.1097/MD.0000000000024283
PMID:33663047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7909171/
Abstract

ABSTRACT

Attention-deficit/hyperactivity disorder (ADHD) is characterized by a persistent pattern of inattention and hyperactivity/impulsivity. Despite the proven efficacy of pharmacological treatment, many individuals continue to suffer socially and academically and some experience significant side effects that negate the use psychotropic drugs. Transcranial direct current stimulation (tDCS) is a cortical neuromodulation feature that has shown positive results in the treatment of various neuropsychiatric conditions.

OBJECTIVES

To investigate the effect of tDCS on the performance of children and adolescents with ADHD in the neuropsychological tests of visual attention, verbal, and inhibitory control.

METHODOLOGY

Triple blind, randomized, sham-controlled, cross-over trial involving tDCS in children and adolescents with ADHD. Initial screening will be performed using Swanson, Nolan, and Pelham - IVand Wechsler intelligence scale for children fourth edition vocabulary and cube subtests. Individuals will be evaluated pre-tDCS and post-tDCS with the Wechsler intelligence scale for children fourth edition Digitus subtest, neuropsychological assessment battery second edition inhibiting responses subtest, Corsi cubes, and visual attention test-4.

摘要

摘要

注意力缺陷多动障碍(ADHD)的特征是持续存在注意力不集中和多动/冲动。尽管药物治疗已被证明有效,但许多人仍在社交和学业上受到困扰,有些人还经历了严重的副作用,从而否定了使用精神药物。经颅直流电刺激(tDCS)是一种皮层神经调节特征,已在治疗各种神经精神疾病方面显示出积极的结果。

目的

研究 tDCS 对注意力缺陷多动障碍儿童和青少年在视觉注意力、言语和抑制控制神经心理学测试中的表现的影响。

方法

这是一项涉及 ADHD 儿童和青少年 tDCS 的三盲、随机、假对照、交叉试验。初步筛选将使用 Swanson、Nolan 和 Pelham-IV 以及韦氏儿童智力量表第四版词汇和立方子测验进行。个体将在 tDCS 前和 tDCS 后进行韦氏儿童智力量表第四版 Digitus 子测验、神经心理学评估电池第二版抑制反应子测验、Corsi 立方体和视觉注意测试-4 评估。