Department of Paediatrics, Yenepoya Medical College, Mangalore, India.
Department of Microbiology, Yenepoya Medical College, Mangalore, India.
Sci Rep. 2021 Mar 4;11(1):5116. doi: 10.1038/s41598-021-84293-8.
The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Antimicrobial resistance (AMR) patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand the local priority pathogens. Culture reports of laboratory specimens collected between 1st January 2014 and 31st October 2019 from paediatric patients were extracted. The antimicrobial susceptibility patterns for selected antimicrobials on the WHO PPL were analysed and reported. Of 12,256 culture specimens screened, 2335 (19%) showed culture positivity, of which 1556 (66.6%) were organisms from the WHO-PPL. E. coli was the most common organism isolated (37%), followed by Staphylococcus aureus (16%). Total of 72% of E. coli were extended-spectrum beta-lactamases (ESBL) producers, 55% of Enterobacteriaceae were resistant to 3rd generation cephalosporins due to ESBL, and 53% of Staph. aureus were Methicillin-resistant. The analysis showed AMR trends and prevalence patterns in the study setting and the WHO-PPL document are not fully comparable. This kind of local priority difference needs to be recognised in local policies and practices.
世界卫生组织（WHO）制定了优先病原体清单（PPL），为研究和开发新的抗菌药物提供了战略方向。本研究旨在了解当地的优先病原体，探索了印度南部一家三级医疗机构中 WHO PPL 的抗菌药物耐药模式。提取了 2014 年 1 月 1 日至 2019 年 10 月 31 日期间从儿科患者采集的实验室标本的培养报告。分析并报告了针对 WHO PPL 上选定抗菌药物的药敏模式。在筛查的 12256 份培养标本中，有 2335 份（19%）显示培养阳性，其中 1556 份（66.6%）来自 WHO-PPL。大肠杆菌是最常见的分离菌（37%），其次是金黄色葡萄球菌（16%）。大肠杆菌中共有 72%为产超广谱β-内酰胺酶（ESBL）的菌株，55%的肠杆菌科由于 ESBL 对第三代头孢菌素耐药，53%的金黄色葡萄球菌为耐甲氧西林的菌株。分析显示，研究环境中的抗菌药物耐药趋势和流行模式与 WHO-PPL 文件不完全可比。这种当地优先差异需要在当地政策和实践中得到认可。
