Zimmerli W, Gallin J I
Department of Research and Internal Medicine, University Hospital, Basel, Switzerland.
Inflammation. 1988 Feb;12(1):37-43. doi: 10.1007/BF00915890.
Membrane depolarization is an early event in cell stimulation. Since the resting membrane potential is dependent on the potassium composition of the extracellular medium, we investigated whether there are clinical situations in which potassium levels are high enough to depolarize polymorphonuclear leukocytes. We determined the ionic composition of sterile and infected interstitial fluid in humans and guinea pigs. All sterile extravascular fluids had physiological potassium levels in the same range as serum values. In contrast, human abscess fluids contained increased K+-levels (17 +/- 6.4 mmol/liter, N = 8) and 15 of 20 experimental abscesses in guinea pigs contained greater than 10 mmol/liter K+. In humans three of eight abscess fluid K+ levels and in guinea pigs three of five abscess fluid K+ levels were even greater than 15 mmol/liter. Thus, high K+ levels, previously shown to activate polymorphonuclear leukocytes, are observed in certain clinical situations associated with local inflammation.
膜去极化是细胞刺激中的早期事件。由于静息膜电位取决于细胞外介质的钾成分，我们研究了是否存在钾水平高到足以使多形核白细胞去极化的临床情况。我们测定了人和豚鼠无菌及感染性间质液的离子组成。所有无菌血管外液的生理钾水平与血清值处于相同范围。相比之下，人脓肿液中的钾离子水平升高（17±6.4毫摩尔/升，N = 8），豚鼠20个实验性脓肿中有15个的钾离子含量大于10毫摩尔/升。在人类中，8个脓肿液中的3个钾离子水平以及豚鼠5个脓肿液中的3个钾离子水平甚至大于15毫摩尔/升。因此，先前已证明能激活多形核白细胞的高钾水平在某些与局部炎症相关的临床情况中可见。
