Nervi F, Duarte I, Gómez G, Rodríguez G, Del Pino G, Ferrerio O, Covarrubias C, Valdivieso V, Torres M I, Urzúa A
Department of Gastroenterology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago.
Int J Cancer. 1988 May 15;41(5):657-60. doi: 10.1002/ijc.2910410503.
We report an autopsy study of gallbladder cancer prevalence in Chile, where the risk of this disease is among the highest reported world-wide. In 14,768 autopsy protocols obtained from 3 university hospitals, 45% of women and 20% of men older than 20 years had gallstone disease (the major known risk factor for gallbladder cancer). The prevalence of gallbladder cancer in Chileans was compared to that found in a Swedish-Czechoslovakian autopsy study previously published. These countries were chosen because of their high frequency of gallstone disease. The comparison was performed by using logistic regression models adjusting for possible differences in the age-sex structure or the true incidence of gallstones in both populations. We found that the most important single risk factor for gallbladder cancer in Chile was gallstone disease, with an estimated effect on the logistic scale meaning that the cancer risk for subjects with gallstones is seven times higher than for those without the disease. Second in importance was the risk for sex, women being 2.8 times higher than for men. The estimated difference in the sex composition and the incidence of gallstones resulted in 17.9% higher odds of cancer in Chile than in Sweden and Czechoslovakia. However, this difference was not significant. This study suggests that the major etiologic factors of gallbladder cancer in Chileans, Swedes and Czechoslovakians are primarily related to gallstone disease.
我们报告了一项关于智利胆囊癌患病率的尸检研究，该国这种疾病的风险在全球报告中位居前列。在从3所大学医院获取的14768份尸检报告中，20岁以上的女性中有45%、男性中有20%患有胆结石疾病（胆囊癌已知的主要风险因素）。将智利人的胆囊癌患病率与先前发表的一项瑞典 - 捷克斯洛伐克尸检研究中的结果进行了比较。选择这两个国家是因为它们胆结石疾病的高发率。通过使用逻辑回归模型进行比较，以调整两个群体在年龄 - 性别结构或胆结石实际发病率方面可能存在的差异。我们发现，智利胆囊癌最重要的单一风险因素是胆结石疾病，在逻辑尺度上的估计效应表明，有胆结石的受试者患癌风险比没有该疾病的人高7倍。重要性位居第二的是性别风险，女性的风险比男性高2.8倍。智利在性别构成和胆结石发病率方面的估计差异导致其患癌几率比瑞典和捷克斯洛伐克高17.9%。然而，这种差异并不显著。这项研究表明，智利人、瑞典人和捷克斯洛伐克人患胆囊癌的主要病因因素主要与胆结石疾病有关。
