Hou J, Zheng W F
Department of Immunology, Tianjin Medical College, People's Republic of China.
Int J Immunopharmacol. 1988;10(1):15-22. doi: 10.1016/0192-0561(88)90145-2.
The effect of pharmacologic doses of sex hormones on NK and ADCC activity against YAC-1 lymphoma and CRBC target cells was studied. Estradiol (E) and testosterone (T) administration for 2 weeks caused a substantial reduction of splenic NK activity in TA3 mice of either sex. In prolonging the treatment time, the intensity of suppression was gradually increased. Both E and T have apparently no inhibitory effect on ADCC activity of TA3 mice, although the ADCC activity slightly increased in the early stage of T treatment. The ADCC activity of T-treated male mice was slightly higher than that of E-treated males. Passive transfer of the splenic mononuclear cells and serum of treated mice does not affect the NK and ADCC activity of normal recipient mice. Addition of different concentrations of sex hormones into the culture medium or pre-treatment of effector cells for 12h failed to change the NK and ADCC activity of murine splenic cells.
研究了药理剂量的性激素对针对YAC - 1淋巴瘤和CRBC靶细胞的自然杀伤（NK）及抗体依赖的细胞介导的细胞毒性（ADCC）活性的影响。给予雌二醇（E）和睾酮（T）2周导致任一性别的TA3小鼠脾脏NK活性大幅降低。延长治疗时间，抑制强度逐渐增加。E和T对TA3小鼠的ADCC活性显然没有抑制作用，尽管在T治疗早期ADCC活性略有增加。T处理的雄性小鼠的ADCC活性略高于E处理的雄性小鼠。将处理过的小鼠的脾脏单核细胞和血清进行被动转移不影响正常受体小鼠的NK和ADCC活性。向培养基中添加不同浓度的性激素或对效应细胞预处理12小时未能改变小鼠脾脏细胞的NK和ADCC活性。
