Neilan B A, O'Neill K, Handwerger B S
Toxicol Appl Pharmacol. 1983 Jun 30;69(2):272-5. doi: 10.1016/0041-008x(83)90308-3.
Splenic antibody-dependent, cell-mediated cytotoxicity against chicken red blood cell targets [ADCC (CRBC)] and natural killer cell-mediated cytotoxicity (NKMC) were determined in C57BL/6 mice given 1300 ppm lead acetate (827 ppm lead) in their drinking water for 8 weeks. ADCC in lead exposed mice was significantly lower than controls at effector to target cell ratios of 100:1, 50:1, and 25:1. In contrast, no significant difference in unstimulated NKMC was seen in lead exposed mice and control mice at effector to target cell ratios of 200:1, 100:1, and 50:1. Moreover, in vivo poly I:C-enhanced NKMC in lead-treated mice was similar to controls at an effector to target cell ratio of 200:1. Blood lead levels averaged 40.5 +/- 1.2 micrograms% in lead-exposed mice and 1.9 +/- 0.3 micrograms% in controls. These findings suggest that chronic low-level lead exposure in mice results in significant suppression of ADCC (CRBC) but does not alter natural killer activity.
在饮用含1300 ppm醋酸铅（827 ppm铅）的水8周的C57BL/6小鼠中，测定了脾脏对鸡红细胞靶标的抗体依赖性细胞介导的细胞毒性[ADCC(CRBC)]和自然杀伤细胞介导的细胞毒性（NKMC）。在效应细胞与靶细胞比例为100:1、50:1和25:1时，铅暴露小鼠的ADCC显著低于对照组。相比之下，在效应细胞与靶细胞比例为200:1、100:1和50:1时，铅暴露小鼠和对照小鼠的未刺激NKMC未见显著差异。此外，在效应细胞与靶细胞比例为200:1时，铅处理小鼠体内聚肌胞苷酸增强的NKMC与对照组相似。铅暴露小鼠的血铅水平平均为40.5±1.2微克%，对照组为1.9±0.3微克%。这些发现表明，小鼠长期低水平铅暴露会导致ADCC(CRBC)显著抑制，但不会改变自然杀伤活性。
