社区居住的老年人的体重变化及其与认知衰退的纵向关联。
Body weight changes and longitudinal associations with cognitive decline among community-dwelling older adults.
作者信息
Eymundsdottir Hrafnhildur, Ramel Alfons, Geirsdottir Olof G, Skuladottir Sigrun S, Gudmundsson Larus S, Jonsson Palmi V, Gudnason Vilmundur, Launer Lenore, Jonsdottir Maria K, Chang Milan
机构信息
Food Science and Nutrition University of Iceland Reykjavik Iceland.
The Icelandic Gerontological Research Center the National University Hospital of Iceland Reykjavik Iceland.
出版信息
Alzheimers Dement (Amst). 2021 Feb 20;13(1):e12163. doi: 10.1002/dad2.12163. eCollection 2021.
INTRODUCTION
We aim to investigate the longitudinal associations between changes in body weight (BW) and declines in cognitive function and risk of mild cognitive impairment (MCI)/dementia among cognitively normal individuals 65 years or older.
METHODS
Data from the Age Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik Study) including 2620 participants, were examined using multiple logistic regression models. Cognitive function included speed of processing (SP), executive function (EF), and memory function (MF). Changes in BW were classified as; weight loss (WL), weight gain (WG), and stable weight (SW).
RESULTS
Mean follow-up time was 5.2 years and 61.3% were stable weight. Participants who experienced WL (13.4%) were significantly more likely to have declines in MF and SP compared to the SW group. Weight changes were not associated with EF. WL was associated with a higher risk of MCI, while WG (25.3%) was associated with a higher dementia risk, when compared to SW.
DISCUSSION
Significant BW changes in older adulthood may indicate impending changes in cognitive function.
引言
我们旨在研究65岁及以上认知功能正常个体的体重变化与认知功能衰退以及轻度认知障碍（MCI）/痴呆风险之间的纵向关联。
方法
使用多元逻辑回归模型对来自年龄基因/环境易感性-雷克雅未克研究（AGES-雷克雅未克研究）的2620名参与者的数据进行了分析。认知功能包括处理速度（SP）、执行功能（EF）和记忆功能（MF）。体重变化分为：体重减轻（WL）、体重增加（WG）和体重稳定（SW）。
结果
平均随访时间为5.2年，61.3%的人体重稳定。与体重稳定组相比，体重减轻（13.4%）的参与者出现记忆功能和处理速度衰退的可能性显著更高。体重变化与执行功能无关。与体重稳定组相比，体重减轻与MCI风险较高相关，而体重增加（25.3%）与痴呆风险较高相关。
讨论
成年后期显著的体重变化可能预示着认知功能即将发生变化。
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