静止造血干细胞中溶酶体对代谢的调控：不仅仅是自噬。
Lysosomal Regulation of Metabolism in Quiescent Hematopoietic Stem Cells: More than Just Autophagy.
机构信息
Departments of Cell, Developmental & Regenerative Biology, Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
出版信息
Cell Stem Cell. 2021 Mar 4;28(3):374-377. doi: 10.1016/j.stem.2021.02.017.
Abstract
The depth of quiescence in hematopoietic stem cells (HSCs) dictates their potency and is sensitive to metabolic perturbations. Recent evidence suggests that lysosomal functions distinct from autophagic processes are pivotal in regulating quiescence versus activation by potential control of the access to a nutrient reservoir required for HSC activation.
摘要
造血干细胞（HSCs）的静止深度决定了它们的效力，并且对代谢扰动敏感。最近的证据表明，溶酶体的功能不同于自噬过程，对于控制 HSC 激活所需的营养储备的获取，从而调节静止与激活状态具有关键作用。
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