Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034, Barcelona, Catalonia, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Spain.
Department of Organic Chemistry, University of La Laguna, Avda. Astrofísico Francisco Sánchez 3, 38206, La Laguna, Tenerife, Spain; Institute of Bio-Organic Antonio González, University of La Laguna, Avda. Astrofísico Francisco Sánchez 3, 38206, La Laguna, Tenerife, Spain; Institute of Organic Chemistry, University of Regensburg, Universitätstr. 31, Regensburg, 93053, Germany.
Neurochem Int. 2021 Jul;147:105005. doi: 10.1016/j.neuint.2021.105005. Epub 2021 Mar 3.
Peripheral nerve injury (PNI) is a serious clinical health problem caused by the damage of peripheral nerves which results in neurological deficits and permanent disability. There are several factors that may cause PNI such as localized damage (car accident, trauma, electrical injury) and outbreak of the systemic diseases (autoimmune or diabetes). While various diagnostic procedures including X-ray, magnetic resonance imaging (MRI), as well as other type of examinations such as electromyography or nerve conduction studies have been efficiently developed, a full recovery in patients with PNI is in many cases deficient or incomplete. This is the reason why additional therapeutic strategies should be explored to favor a complete rehabilitation in order to get appropriate nerve injury regeneration. The use of biomaterials acting as scaffolds opens an interesting approach in regenerative medicine and tissue engineering applications due to their ability to guide the growth of new tissues, adhesion and proliferation of cells including the expression of bioactive signals. This review discusses the preparation and therapeutic strategies describing in vitro and in vivo experiments using graphene-based materials in the context of PNI and their ability to promote nerve tissue regeneration.
周围神经损伤（PNI）是一种严重的临床健康问题，由周围神经损伤引起，导致神经功能缺损和永久性残疾。有几个因素可能导致 PNI，如局部损伤（车祸、创伤、电击伤）和系统性疾病（自身免疫性或糖尿病）的爆发。虽然已经开发出包括 X 射线、磁共振成像（MRI）以及肌电图或神经传导研究等其他类型的检查在内的各种诊断程序，但 PNI 患者的完全康复在许多情况下是不足或不完全的。这就是为什么应该探索额外的治疗策略以促进完全康复，从而获得适当的神经损伤再生的原因。生物材料作为支架的使用在再生医学和组织工程应用中开辟了一个有趣的方法，因为它们能够引导新组织的生长、细胞的黏附和增殖，包括生物活性信号的表达。本文综述了在 PNI 背景下使用基于石墨烯的材料进行体外和体内实验的制备和治疗策略及其促进神经组织再生的能力。
