Division of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Division of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China; Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
J Affect Disord. 2021 May 1;286:27-32. doi: 10.1016/j.jad.2021.02.039. Epub 2021 Feb 17.
Little is known how often depressive episodes are accompanied by gastrointestinal symptoms in major depressive disorders (MDD). The authors sought to determine the frequency and clinical correlates of gastrointestinal symptoms during episodes of depressive disorder.
3,256 MDD patients from the National Survey on Symptomatology of Depression (NSSD), which was designed to investigate the magnitude of symptoms of current major depressive episodes in China, were enrolled and assessed for gastrointestinal symptoms in this study. Illness characteristics were compared in patients with a different frequency of gastrointestinal symptoms. Pearson correlation analysis and multiple linear regression analysis were employed to investigate the associations between gastrointestinal symptoms and psychological characteristics in the patients.
More than 70% of the subjects with depressive episodes had concomitant gastrointestinal symptoms. A higher frequency of gastrointestinal symptoms was associated with an increased risk of suicide ideation, suicide attempts, anxious mood, depressed mood, insomnia, feeling a failure, poor concentration, body pain, hopelessness, anger, and irritability. Pearson correlation analysis indicated moderate but significant associations between gastrointestinal symptoms and psychological characteristics (p<0.001). Multiple linear regression analysis showed that suicide ideation (β=0.161, p<0.001), anxiety mood (β=0.166, p = 0.006), insomnia (β =0.262, p<0.001), anger (β=0.144, p<0.001), feeling a failure (β =0.365, p<0.001), and body pain (β=0.581 p<0.001) were independently associated with gastrointestinal symptoms in MDD patients.
Gastrointestinal symptoms were one of the most prevalent clinical presentations of MDD. The associations between gastrointestinal symptoms and psychological characteristics may prove useful in expanding our understanding of how gastrointestinal symptoms contributes to MDD.
在重度抑郁症（MDD）中，抑郁发作时常伴有胃肠道症状的情况鲜为人知。作者旨在确定抑郁障碍发作期间胃肠道症状的发生频率和临床相关性。
本研究纳入了 3256 名来自中国国家症状调查抑郁研究（NSSD）的 MDD 患者，该研究旨在调查中国当前重度抑郁发作症状的严重程度，并评估这些患者的胃肠道症状。比较了不同胃肠道症状频率患者的疾病特征。采用 Pearson 相关分析和多元线性回归分析来探讨胃肠道症状与患者心理特征之间的相关性。
超过 70%的抑郁发作患者伴有胃肠道症状。胃肠道症状出现的频率越高，自杀意念、自杀未遂、焦虑情绪、抑郁情绪、失眠、失败感、注意力不集中、躯体疼痛、绝望感、愤怒和易怒的风险越高。Pearson 相关分析表明胃肠道症状与心理特征之间存在中度但显著的相关性（p<0.001）。多元线性回归分析表明自杀意念（β=0.161，p<0.001）、焦虑情绪（β=0.166，p=0.006）、失眠（β=0.262，p<0.001）、愤怒（β=0.144，p<0.001）、失败感（β=0.365，p<0.001）和躯体疼痛（β=0.581，p<0.001）与 MDD 患者的胃肠道症状独立相关。
胃肠道症状是 MDD 最常见的临床表现之一。胃肠道症状与心理特征之间的相关性可能有助于我们进一步了解胃肠道症状对 MDD 的影响。
