Knowles Corey M, McIntyre Kelcy M, Panepinto John C
Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14201, USA.
J Fungi (Basel). 2021 Feb 24;7(3):159. doi: 10.3390/jof7030159.
is a ubiquitous environmental fungus capable of establishing an infection in a human host. Rapid changes in environments and exposure to the host immune system results in a significant amount of cellular stress, which is effectively combated at the level of translatome reprogramming. Repression of translation following stress allows for the specific reallocation of limited resources. Understanding the mechanisms involved in regulating translation in during host infection is critical in the development of new antifungal drugs. In this review, we discuss the main tools available for assessing changes in translation state and translational output during cellular stress.
是一种普遍存在的环境真菌，能够在人类宿主中引发感染。环境的快速变化以及暴露于宿主免疫系统会导致大量细胞应激，而这种应激在转录组重编程水平上能得到有效应对。应激后翻译的抑制使得有限资源得以特定重新分配。了解宿主感染期间调节翻译的机制对于新型抗真菌药物的研发至关重要。在本综述中，我们讨论了可用于评估细胞应激期间翻译状态和翻译产出变化的主要工具。
