He Mincong, Kolhoff Frank, Mont Michael A, Parvizi Javad
The Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510000, China.
International Joint Center, Acibadem Maslak Hospital, Istanbul 34303, Turkey.
Antibiotics (Basel). 2025 Jun 15;14(6):609. doi: 10.3390/antibiotics14060609.
Osteoarthritis (OA) has traditionally been defined as a degenerative joint disease driven by mechanical wear, aging, and metabolic disturbances. However, emerging evidence suggests that joint dysbiosis, a dysregulation in the joint microbiome, may play an important role in OA pathogenesis. This review explores the mechanisms linking dysbiosis to OA. We examine the presence and origin of joint dysbiosis, also highlighting the gut-joint and oral-joint axes as potential routes for microbial translocation. However, challenges remain in distinguishing causation from correlation and addressing microbial contaminants in microbiome studies. Future research should prioritize longitudinal studies and multiomics integration to elucidate the complex interplay between microbial communities and joint health.
骨关节炎（OA）传统上被定义为一种由机械磨损、衰老和代谢紊乱驱动的退行性关节疾病。然而，新出现的证据表明，关节生态失调，即关节微生物群的失调，可能在OA发病机制中起重要作用。本综述探讨了将生态失调与OA联系起来的机制。我们研究了关节生态失调的存在和起源，同时强调了肠道-关节轴和口腔-关节轴作为微生物易位的潜在途径。然而，在区分因果关系和解决微生物组研究中的微生物污染物方面仍然存在挑战。未来的研究应优先进行纵向研究和多组学整合，以阐明微生物群落与关节健康之间的复杂相互作用。
