Oh Yun Hwan, Choi Seulggie, Lee Gyeongsil, Son Joung Sik, Kim Kyae Hyung, Park Sang Min
Department of Family Medicine, Jeju National University Hospital, Jeju 63241, Korea.
Department of Family Medicine, School of Medicine, Jeju National University, Jeju 63243, Korea.
J Clin Med. 2021 Feb 13;10(4):745. doi: 10.3390/jcm10040745.
In a cohort of 190,599 participants from The National Health Insurance Service-National Health Screening (NHIS-HEALS) study, we investigated the association of changes in the predicted body composition and metabolic profiles with the risk of metabolic syndrome (MetS) in the general population, which was hitherto incompletely elucidated. At baseline and follow-up examinations, the body composition, including lean body mass (LBM), body fat mass (BFM), and appendicular skeletal mass (ASM), were estimated using a prediction equation, and the risk of MetS was analyzed according to relative body composition changes. An increase in relative LBM and ASM decreased the risk of MetS in men and women (adjusted odds ratio (aOR), 0.78 and 0.80; 95% confidence interval (CI), 0.77-0.79 and 0.79-0.81, respectively; all < 0.001). As relative LBM and ASM increased, the risk of MetS was more significantly reduced in the group with higher baseline BMI and body fat mass index (BFMI)(all -trend < 0.001). In men, when the relative LBM increased (aOR, 0.68; 95% CI, 0.63-0.73), the risk of MetS was low despite increased BMI. Thus, our findings suggested that an increase in the relative LBM and ASM reduced the risk of MetS, whereas an increase in the relative BFMI increased the risk of MetS; this result was consistent in men despite an increase in BMI.
在一项来自韩国国民健康保险服务-国民健康筛查（NHIS-HEALS）研究的190,599名参与者队列中，我们调查了预测身体成分和代谢谱的变化与一般人群中代谢综合征（MetS）风险之间的关联，此前这一关联尚未完全阐明。在基线和随访检查中，使用预测方程估算包括瘦体重（LBM）、体脂肪量（BFM）和四肢骨骼肌量（ASM）在内的身体成分，并根据相对身体成分变化分析MetS风险。相对LBM和ASM的增加降低了男性和女性患MetS的风险（调整优势比（aOR）分别为0.78和0.80；95%置信区间（CI）分别为0.77-0.79和0.79-0.81；均P<0.001）。随着相对LBM和ASM的增加，在基线BMI和体脂肪质量指数（BFMI）较高的组中，MetS风险降低得更显著（所有趋势P<0.001）。在男性中，当相对LBM增加时（aOR，0.68；95%CI，0.63-0.73），尽管BMI增加，但MetS风险较低。因此，我们的研究结果表明，相对LBM和ASM的增加降低了MetS风险，而相对BFMI的增加则增加了MetS风险；在男性中，尽管BMI增加，这一结果仍然一致。
