Future Convergence Research Institute, Changwon National University, Changwon, Republic of Korea.
Human Community Renovation Research Center, R Professional University of Rehabilitation, Tsuchiura, Japan.
Front Public Health. 2024 Oct 30;12:1469196. doi: 10.3389/fpubh.2024.1469196. eCollection 2024.
Aging and obesity are considered causes of arterial stiffness, which triggers hypertension in the older population. However, a substantial number of older adults without obesity have hypertension, suggesting that arterial stiffness and hypertension are related to different risk factors in older adults without obesity. This cross-sectional study aimed to determine whether sarcopenia is related to arterial stiffness or hypertension in older Korean adults without underweight and obesity.
A total of 2,237 male and female adults in the Korea National Health and Nutritional Examination Survey who were ≥60 years and did not have underweight and obesity (18.5 ≤ body mass index <25.0 kg/m) were involved. They were classified as moderate- ( = 276) or severe-sarcopenia ( = 528) as their sarcopenia index was 1 or 2 standard deviations lower than the mean of the young reference group. Arterial stiffness was confirmed using an estimated pulse wave velocity (ePWV) formula, and hypertension was diagnosed based on blood pressure or antihypertensive medication use.
Arterial stiffness and systolic and diastolic blood pressure showed an increasing trend from normal to moderate-to-severe sarcopenia ( < 0.001 for both). The distribution of subjects in the highest ePWV tertile and hypertension from normal to moderate-to-severe sarcopenia showed an increasing trend ( < 0.001 for both). Subjects with moderate or severe sarcopenia were 3.545 or 8.903 times more likely to be in the highest tertile of ePWV, and those with moderate or severe sarcopenia were 2.106 or 11.725 times more likely to be hypertension ( < 0.001 for all).
Sarcopenia severity is related to arterial stiffness and hypertension in older Korean populations without underweight and obesity.
衰老和肥胖被认为是动脉僵硬的原因，这会引发老年人群的高血压。然而，大量没有肥胖的老年人患有高血压，这表明动脉僵硬和高血压与没有肥胖的老年人的不同危险因素有关。本横断面研究旨在确定在没有消瘦和肥胖的韩国老年人群中，肌肉减少症是否与动脉僵硬或高血压有关。
共有 2237 名年龄在 60 岁及以上且没有消瘦和肥胖（18.5 ≤ BMI <25.0 kg/m）的韩国国家健康和营养检查调查的男性和女性成年人参与了这项研究。他们被分为中度（ = 276）或严重肌肉减少症（ = 528），因为他们的肌肉减少症指数比年轻参考组的平均值低 1 或 2 个标准差。动脉僵硬通过估计脉搏波速度（ePWV）公式来确认，高血压根据血压或使用降压药物来诊断。
动脉僵硬和收缩压及舒张压从正常到中重度肌肉减少症呈递增趋势（两者均 < 0.001）。ePWV 最高三分位和高血压从正常到中重度肌肉减少症的受试者分布呈递增趋势（两者均 < 0.001）。中度或重度肌肉减少症患者处于 ePWV 最高三分位的可能性分别增加 3.545 倍和 8.903 倍，中度或重度肌肉减少症患者患有高血压的可能性分别增加 2.106 倍和 11.725 倍（所有均 < 0.001）。
在没有消瘦和肥胖的韩国老年人群中，肌肉减少症的严重程度与动脉僵硬和高血压有关。
