Velázquez-Delgado Perla I, Gutierrez-Blanco Eduardo, Torres-Acosta Felipe de J, Ortega-Pacheco Antonio, Aguilar-Caballero Armando J, Dzikiti Brighton T
Department of Animal Health and Preventive Medicine, Autonomous University of Yucatan, 97000 Merida, Mexico.
Department of Large Animal Clinical Science, School of Veterinary Medicine, Ross University, KN0111 Basseterre, Saint Kitts and Nevis.
Animals (Basel). 2021 Feb 13;11(2):492. doi: 10.3390/ani11020492.
This study aimed to compare, first, the anesthetic and cardiopulmonary effects of propofol or isoflurane anesthetic maintenance in goats receiving a fentanyl-lidocaine-ketamine infusion undergoing abomasotomy and, secondly, to compare the quality of the recovery from anesthesia. Two groups were used: propofol (TIVA) and isoflurane (PIVA). Goats were premedicated with fentanyl (10 μg/kg intravenously [IV]), lidocaine (2 mg/kg, IV), and ketamine (1.5 mg/kg, IV). Anesthesia was induced with propofol and maintenance consisted of fentanyl (10 μg/kg/h, IV), lidocaine (50 μg/kg/min, IV), and ketamine (50 μg/kg/min, IV) as constant-rate infusions (CRIs), combined with either CRI of propofol at initial dose of 0.3 mg/kg/min, IV (TIVA), or isoflurane with initial end-tidal (FE'Iso) concentration of 1.2% partial intravenous anesthesia (PIVA). The mean effective propofol dose for maintenance was 0.44 ± 0.07 mg/kg/min, while the mean FE'Iso was 0.81 ± 0.2%. Higher systolic arterial pressure (SAP) values were observed in total intravenous anesthesia (TIVA) during some time points. Recovery was smooth in PIVA, while restlessness, vocalizations, and paddling were observed in TIVA. Both protocols produced a satisfactory quality of anesthesia during surgery, with minimal impact on cardiopulmonary function. Nevertheless, recovery after anesthesia in TIVA might be of poor quality.
本研究旨在，首先，比较在接受芬太尼 - 利多卡因 - 氯胺酮输注并进行皱胃切开术的山羊中，丙泊酚或异氟烷麻醉维持的麻醉效果和心肺效应；其次，比较麻醉苏醒质量。使用了两组：丙泊酚组（全凭静脉麻醉 [TIVA]）和异氟烷组（部分静脉麻醉 [PIVA]）。山羊术前用芬太尼（10 μg/kg静脉注射 [IV]）、利多卡因（2 mg/kg，IV）和氯胺酮（1.5 mg/kg，IV）进行预处理。麻醉诱导用丙泊酚，维持由芬太尼（10 μg/kg/h，IV）、利多卡因（50 μg/kg/min，IV）和氯胺酮（50 μg/kg/min，IV）以恒速输注（CRIs）组成，联合初始剂量为0.3 mg/kg/min的丙泊酚CRI，IV（TIVA），或初始呼气末（FE'Iso）浓度为1.2%的异氟烷部分静脉麻醉（PIVA）。维持用丙泊酚的平均有效剂量为0.44 ± 0.07 mg/kg/min，而平均FE'Iso为0.81 ± 0.2%。在某些时间点，全凭静脉麻醉（TIVA）中观察到较高的收缩动脉压（SAP）值。PIVA组苏醒平稳，而TIVA组观察到躁动、鸣叫和划动。两种方案在手术期间均产生了令人满意的麻醉质量，对心肺功能影响最小。然而，TIVA组麻醉后的苏醒质量可能较差。
