18F-FDG PET/CT不能替代内镜用于套细胞淋巴瘤胃肠道受累的分期。一项回顾性多中心队列分析。
18F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort Analysis.
作者信息
Skrypets Tetiana, Ferrari Cristina, Nassi Luca, Margiotta Casaluci Gloria, Puccini Benedetta, Mannelli Lara, Filonenko Kateryna, Kryachok Irina, Clemente Felice, Vegliante Maria Carmela, Daniele Antonella, Sacchetti Gianmauro, Guarini Attilio, Minoia Carla
机构信息
Haematology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.
D.I.M.-Diagnostic Imaging-Nuclear Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
出版信息
J Pers Med. 2021 Feb 13;11(2):123. doi: 10.3390/jpm11020123.
The detection of gastrointestinal (GI) involvement in Mantle Cell Lymphoma is often underestimated and may have an impact on outcome and clinical management. We aimed to evaluate whether baseline 18F-FDG PET/CT presents comparable results to endoscopic biopsy in the diagnosis of GI localizations. In our retrospective cohort of 79 patients, sensitivity and specificity of 18F-FDG PET/CT were low for the stomach, with a fair concordance ( = 0.32), while higher concordance with pathologic results ( = 0.65) was detected in the colorectal tract. Thus, gastric biopsy remains helpful in the staging of MCL despite 18F-FDG PET/CT, while colonoscopy could be omitted in asymptomatic patients. The validation of our data in prospective cohorts is desirable.
套细胞淋巴瘤胃肠道受累的检测常常被低估，可能会对预后和临床管理产生影响。我们旨在评估基线18F-FDG PET/CT在胃肠道定位诊断中是否与内镜活检结果相当。在我们79例患者的回顾性队列中，18F-FDG PET/CT对胃的敏感性和特异性较低，一致性一般（κ = 0.32），而在结直肠部位与病理结果的一致性较高（κ = 0.65）。因此，尽管有18F-FDG PET/CT，胃活检对于套细胞淋巴瘤的分期仍有帮助，而对于无症状患者可以省略结肠镜检查。在未来前瞻性队列中验证我们的数据是很有必要的。
Zotero 插件