尿液中色氨酸相关荧光与恶性黑色素瘤之间存在强烈的相关性。

Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Tr. SNP 1, 040 11 Košice, Slovakia.

Department of Chemistry, Biochemistry and Biophysics, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia.

Int J Mol Sci. 2021 Feb 13;22(4):1884. doi: 10.3390/ijms22041884.

Urine autofluorescence at 295 nm is significantly higher in patients with malignant melanoma at each clinical stage compared to the healthy group. The largest difference is in the early-stages and without metastases. With increasing stage, the autofluorescence at 295 nm decreases. There is also a significant negative correlation between autofluorescence and Clark classification. Based on our results, it is assumed that the way malignant melanoma grows also affects urinary autofluorescence.

在 295nm 处的尿液自体荧光在每个临床阶段的恶性黑色素瘤患者中均显著高于健康组。最大的差异出现在早期且无转移的阶段。随着阶段的增加，295nm 处的自体荧光减少。自体荧光与 Clark 分级之间也存在显著的负相关。基于我们的结果，可以假设恶性黑色素瘤的生长方式也会影响尿液自体荧光。