• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

尿液中色氨酸相关荧光与恶性黑色素瘤之间存在强烈的相关性。

Strong Dependence between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma.

机构信息

Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Tr. SNP 1, 040 11 Košice, Slovakia.

Department of Chemistry, Biochemistry and Biophysics, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia.

出版信息

Int J Mol Sci. 2021 Feb 13;22(4):1884. doi: 10.3390/ijms22041884.

DOI:10.3390/ijms22041884
PMID:33668679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7917726/
Abstract

Urine autofluorescence at 295 nm is significantly higher in patients with malignant melanoma at each clinical stage compared to the healthy group. The largest difference is in the early-stages and without metastases. With increasing stage, the autofluorescence at 295 nm decreases. There is also a significant negative correlation between autofluorescence and Clark classification. Based on our results, it is assumed that the way malignant melanoma grows also affects urinary autofluorescence.

摘要

在 295nm 处的尿液自体荧光在每个临床阶段的恶性黑色素瘤患者中均显著高于健康组。最大的差异出现在早期且无转移的阶段。随着阶段的增加，295nm 处的自体荧光减少。自体荧光与 Clark 分级之间也存在显著的负相关。基于我们的结果，可以假设恶性黑色素瘤的生长方式也会影响尿液自体荧光。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/6ac4d91b447c/ijms-22-01884-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/548f71813949/ijms-22-01884-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/8cfabc863d9d/ijms-22-01884-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/50f2399c12fc/ijms-22-01884-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/0a6148d76f31/ijms-22-01884-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/265d27bc6090/ijms-22-01884-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/f3b45e8908de/ijms-22-01884-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/6ac4d91b447c/ijms-22-01884-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/548f71813949/ijms-22-01884-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/8cfabc863d9d/ijms-22-01884-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/50f2399c12fc/ijms-22-01884-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/0a6148d76f31/ijms-22-01884-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/265d27bc6090/ijms-22-01884-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/f3b45e8908de/ijms-22-01884-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aadd/7917726/6ac4d91b447c/ijms-22-01884-g007.jpg

相似文献

1
Strong Dependence between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma.尿液中色氨酸相关荧光与恶性黑色素瘤之间存在强烈的相关性。
Int J Mol Sci. 2021 Feb 13;22(4):1884. doi: 10.3390/ijms22041884.
2
Specific Urinary Metabolites in Malignant Melanoma.恶性黑色素瘤的特定尿液代谢物。
Medicina (Kaunas). 2019 May 16;55(5):145. doi: 10.3390/medicina55050145.
3
Non-invasive Characterization of Glycosuria and Identification of Biomarkers in Diabetic Urine Using Fluorescence Spectroscopy and Machine Learning Algorithm.使用荧光光谱和机器学习算法无创性特征分析糖尿病人尿液中的糖和鉴定生物标志物。
J Fluoresc. 2024 May;34(3):1391-1399. doi: 10.1007/s10895-023-03366-1. Epub 2023 Aug 3.
4
The potential of autofluorescence spectroscopy to detect human urinary tract infection.利用自发荧光光谱技术检测人类尿路感染的潜力。
Talanta. 2010 Aug 15;82(3):912-7. doi: 10.1016/j.talanta.2010.05.049. Epub 2010 May 27.
5
Early diagnosis of melanotic melanoma based on laser-induced melanin fluorescence.基于激光诱导黑色素荧光的黑素瘤早期诊断
J Biomed Opt. 2009 May-Jun;14(3):034033. doi: 10.1117/1.3155511.
6
Ocular lens blue autofluorescence cannot be used as a measure of individual cumulative UVR exposure.眼晶状体蓝色自发荧光不能用作个体累积紫外线辐射暴露量的衡量指标。
Photodermatol Photoimmunol Photomed. 2004 Feb;20(1):41-6. doi: 10.1111/j.1600-0781.2004.00062.x.
7
Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients.血清色氨酸浓度降低预示恶性黑色素瘤患者预后不良。
Dermatology. 2007;214(1):8-14. doi: 10.1159/000096906.
8
Urinary excretion of epidermal-type fatty acid-binding protein and S100A7 protein in patients with cutaneous melanoma.
Melanoma Res. 2002 Dec;12(6):627-31. doi: 10.1097/00008390-200212000-00013.
9
Simultaneous determination of three potential cancer biomarkers in rat urine by synchronous fluorescence spectroscopy.同步荧光光谱法同时测定大鼠尿液中的三种潜在癌症生物标志物
Spectrochim Acta A Mol Biomol Spectrosc. 2014;120:595-601. doi: 10.1016/j.saa.2013.12.001. Epub 2013 Dec 4.
10
S100B protein, 5-S-cysteinyldopa and 6-hydroxy-5-methoxyindole-2-carboxylic acid as biochemical markers for survival prognosis in patients with malignant melanoma.S100B蛋白、5-S-半胱氨酰多巴和6-羟基-5-甲氧基吲哚-2-羧酸作为恶性黑色素瘤患者生存预后的生化标志物。
Melanoma Res. 1997 Oct;7(5):393-9. doi: 10.1097/00008390-199710000-00005.

引用本文的文献

1
Clinical utility of various liquid biopsy samples for the early detection of ovarian cancer: a comprehensive review.各种液体活检样本在卵巢癌早期检测中的临床应用：一项综述
Front Oncol. 2025 Jul 1;15:1594100. doi: 10.3389/fonc.2025.1594100. eCollection 2025.
2
Non-Invasive Endometrial Cancer Screening through Urinary Fluorescent Metabolome Profile Monitoring and Machine Learning Algorithms.通过尿液荧光代谢组学图谱监测和机器学习算法进行非侵入性子宫内膜癌筛查
Cancers (Basel). 2024 Sep 14;16(18):3155. doi: 10.3390/cancers16183155.
3
Fluorescence-Based Portable Assays for Detection of Biological and Chemical Analytes.

本文引用的文献

1
Urinary fluorescent metabolite O-aminohippuric acid is a useful biomarker for lung cancer detection.尿液荧光代谢产物 O-氨基马尿酸是一种用于肺癌检测的有用生物标志物。
Metabolomics. 2020 Sep 17;16(10):101. doi: 10.1007/s11306-020-01721-y.
2
Significance of 5--Cysteinyldopa as a Marker for Melanoma.5--半胱氨酰多巴作为黑素瘤标志物的意义。
Int J Mol Sci. 2020 Jan 9;21(2):432. doi: 10.3390/ijms21020432.
3
Specific Urinary Metabolites in Malignant Melanoma.恶性黑色素瘤的特定尿液代谢物。
基于荧光的用于生物和化学分析物检测的便携式分析。
Sensors (Basel). 2023 May 25;23(11):5053. doi: 10.3390/s23115053.
4
Tryptophan: Its Metabolism along the Kynurenine, Serotonin, and Indole Pathway in Malignant Melanoma.色氨酸：在恶性黑素瘤中沿着犬尿氨酸、血清素和吲哚途径的代谢。
Int J Mol Sci. 2022 Aug 15;23(16):9160. doi: 10.3390/ijms23169160.
5
Tryptophan in Nutrition and Health.色氨酸在营养与健康中的作用
Int J Mol Sci. 2022 May 13;23(10):5455. doi: 10.3390/ijms23105455.
Medicina (Kaunas). 2019 May 16;55(5):145. doi: 10.3390/medicina55050145.
4
The eighth edition American Joint Committee on Cancer (AJCC) melanoma staging system: implications for melanoma treatment and care.第八版美国癌症联合委员会（AJCC）黑色素瘤分期系统：对黑色素瘤治疗和护理的影响。
Expert Rev Anticancer Ther. 2018 Aug;18(8):775-784. doi: 10.1080/14737140.2018.1489246.
5
ICG fluorescence imaging as a new tool for optimization of pathological evaluation in breast cancer tumors after neoadjuvant chemotherapy.ICG 荧光成像作为新工具，用于优化新辅助化疗后乳腺癌肿瘤的病理评估。
PLoS One. 2018 May 25;13(5):e0197857. doi: 10.1371/journal.pone.0197857. eCollection 2018.
6
The development of fluorescence guided surgery for pancreatic cancer: from bench to clinic.荧光引导手术在胰腺癌中的发展：从基础到临床。
Expert Rev Anticancer Ther. 2018 Jul;18(7):651-662. doi: 10.1080/14737140.2018.1477593. Epub 2018 May 28.
7
Urinary fluorescence analysis in diagnosis of bladder cancer.尿荧光分析在膀胱癌诊断中的应用。
Neoplasma. 2018;65(2):234-241. doi: 10.4149/neo_2018_170610N420.
8
The use of native fluorescence analysis of synovial fluid in the diagnosis of medial compartment disease in medium- and large-breed dogs.
J Vet Diagn Invest. 2016 May;28(3):332-7. doi: 10.1177/1040638716640312. Epub 2016 Mar 26.
9
Current trends in the treatment of malignant melanoma.恶性黑色素瘤治疗的当前趋势。
Neoplasma. 2016;63(3):333-41. doi: 10.4149/301_151015N533.
10
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease.铁、多巴胺和神经黑色素途径在脑衰老和帕金森病中的相互作用。
Prog Neurobiol. 2017 Aug;155:96-119. doi: 10.1016/j.pneurobio.2015.09.012. Epub 2015 Oct 9.