Ramos-Rincón José-Manuel, Ortiz-Martínez Sonia, Vásquez-Chasnamote María-Esteyner, de-Miguel-Balsa Eva, Gamboa-Paredes Olga-Nohelia, Talledo-Albujar Michael-John, López-Campana Giovanni, Celis-Salinas Juan Carlos, Prieto-Pérez Laura, Górgolas-Hernández Miguel, Casapía-Morales Martin
Clinical Medicine Department, Miguel Hernández University of Elche & General University Hospital of Alicante, 03010 Alicante, Spain.
Medical Practice El Ballestero, Health Service of Castilla La Mancha, 02614 Albacete, Spain.
Pathogens. 2021 Feb 25;10(3):260. doi: 10.3390/pathogens10030260.
. Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. The infection is endemic in some areas of Peru, but its prevalence in the Peruvian Amazon is not well established. We aimed to assess the seroprevalence of HTLV-1 infection in pregnant women in the Peruvian Amazon. Moreover, we performed a systematic literature review and meta-analysis of the seroprevalence of HTLV infection in Peru. . This is a prospective cross-sectional study involving pregnant women attending health centers in the city of Iquitos, Peru, in May and June 2019. The presence of antibodies against HTLV-1 was assessed using ELISA (HTLV I + II ELISA recombinant v.4.0, Wiener lab, Rosario, Argentina). Positive cases were confirmed by Western Blot and HTLV-1 proviral load. . The study included 300 pregnant women with a mean age of 26 years (standard deviation [SD] 6.4). Five patients were diagnosed with HTLV-1 infection (prevalence 1.7%, 95% confidence interval (CI) 0.7% to 3.8%). Pregnant women with HTLV-1 infection were discretely younger (mean age 22.6 [SD 22.6] vs 26.8 [SD 6.3]; = 0.128). None of the five women had been transfused, and all were asymptomatic. Two (40%) also had a positive serology for , but larvae were not detected in any of the parasitological stool studies. The systematic review component identified 40 studies, which showed that the prevalence of infection in the general population was 2.9% (95% CI 1.2% to 5.3%) and in women of childbearing age, 2.5% (95% CI 1.2% to 4.0%). . The prevalence of HTLV-1 in the Peruvian Amazon basin is about 1.7%, indicating an endemic presence. Screening for HTLV-1 in prenatal care is warranted.
人类嗜T细胞病毒1型（HTLV-1）可引发热带痉挛性截瘫以及HTLV-1相关白血病/淋巴瘤。该感染在秘鲁的一些地区呈地方性流行，但在秘鲁亚马逊地区的流行情况尚未明确。我们旨在评估秘鲁亚马逊地区孕妇中HTLV-1感染的血清流行率。此外，我们对秘鲁HTLV感染的血清流行率进行了系统的文献综述和荟萃分析。 这是一项前瞻性横断面研究，涉及2019年5月和6月在秘鲁伊基托斯市的健康中心就诊的孕妇。使用酶联免疫吸附测定法（HTLV I + II ELISA重组v.4.0，维纳实验室，阿根廷罗萨里奥）评估抗HTLV-1抗体的存在情况。阳性病例通过蛋白质印迹法和HTLV-1前病毒载量进行确认。 该研究纳入了300名平均年龄为26岁（标准差[SD] 6.4）的孕妇。5名患者被诊断为HTLV-1感染（流行率1.7%，95%置信区间[CI] 0.7%至3.8%）。HTLV-1感染的孕妇明显更年轻（平均年龄22.6 [SD 22.6] 对比26.8 [SD 6.3]；P = 0.128）。这5名女性均未接受过输血，且均无症状。其中两名（40%）的血清学检测也呈阳性，但在任何粪便寄生虫学研究中均未检测到幼虫。系统综述部分共识别出40项研究，结果显示普通人群中HTLV感染的流行率为2.9%（95% CI 1.2%至5.3%），育龄女性中为2.5%（95% CI 1.2%至4.0%）。 秘鲁亚马逊流域HTLV-1的流行率约为1.7%，表明存在地方性流行。产前检查中进行HTLV-1筛查是有必要的。
