Alibi Sana, Crespo Dámaso, Navas Jesús
Analysis and Process Applied to the Environment UR17ES32, Higher Institute of Applied Sciences and Technology, Mahdia 5121, Tunisia.
BIOMEDAGE Group, Faculty of Medicine, Cantabria University, 39011 Santander, Spain.
Antibiotics (Basel). 2021 Feb 25;10(3):231. doi: 10.3390/antibiotics10030231.
The vegetal world constitutes the main factory of chemical products, in particular secondary metabolites like phenols, phenolic acids, terpenoids, and alkaloids. Many of these compounds are small molecules with antibacterial activity, although very few are actually in the market as antibiotics for clinical practice or as food preservers. The path from the detection of antibacterial activity in a plant extract to the practical application of the active(s) compound(s) is long, and goes through their identification, purification, in vitro and in vivo analysis of their biological and pharmacological properties, and validation in clinical trials. This review presents an update of the main contributions published on the subject, focusing on the compounds that showed activity against multidrug-resistant relevant bacterial human pathogens, paying attention to their mechanisms of action and synergism with classical antibiotics.
植物界是化学产品的主要生产厂，尤其是酚类、酚酸、萜类和生物碱等次生代谢产物。这些化合物中有许多是具有抗菌活性的小分子，不过实际上作为临床实践用抗生素或食品防腐剂上市的却很少。从检测植物提取物中的抗菌活性到活性化合物的实际应用，这一过程漫长，要经过对其进行鉴定、纯化、对其生物学和药理学特性进行体外和体内分析，以及在临床试验中进行验证。本综述介绍了该主题已发表的主要研究成果的最新情况，重点关注对多重耐药相关人类病原菌具有活性的化合物，同时关注其作用机制以及与传统抗生素的协同作用。
