Waletzko-Hellwig Janine, Saemann Michael, Schulze Marko, Frerich Bernhard, Bader Rainer, Dau Michael
Department of Oral, Maxillofacial and Plastic Surgery, Rostock University Medical Center, 18057 Rostock, Germany.
Biomechanics and Implant Technology Research Laboratory, Department of Orthopaedics, Rostock University Medical Center, 18057 Rostock, Germany.
Materials (Basel). 2021 Feb 25;14(5):1069. doi: 10.3390/ma14051069.
One main disadvantage of commercially available allogenic bone substitute materials is the altered mechanical behavior due to applied material processing, including sterilization methods like thermal processing or gamma irradiation. The use of high hydrostatic pressure (HHP) might be a gentle alternative to avoid mechanical alteration. Therefore, we compressed ground trabecular human bone to granules and, afterwards, treated them with 250 and 300 MPa for 20 and 30 min respectively. We characterized the formed bone granule cylinders (BGC) with respect to their biomechanical properties by evaluating stiffness and stress at 15% strain. Furthermore, the stiffness and yield strength of HHP-treated and native human trabecular bone cylinders (TBC) as control were evaluated. The mechanical properties of native vs. HHP-treated TBCs as well as HHP-treated vs. untreated BGCs did not differ, independent of the applied HHP magnitude and duration. Our study suggests HHP treatment as a suitable alternative to current processing techniques for allogenic bone substitutes since no negative effects on mechanical properties occurred.
市售同种异体骨替代材料的一个主要缺点是，由于材料加工方式（包括热加工或伽马射线辐照等灭菌方法）的应用，其力学性能会发生改变。使用高静水压（HHP）可能是避免力学性能改变的一种温和替代方法。因此，我们将研磨后的人松质骨压缩成颗粒，然后分别用250兆帕和300兆帕的压力处理20分钟和30分钟。我们通过评估15%应变时的刚度和应力，对形成的骨颗粒圆柱体（BGC）的生物力学性能进行了表征。此外，还评估了经HHP处理的和作为对照的天然人松质骨圆柱体（TBC）的刚度和屈服强度。天然TBC与经HHP处理的TBC以及经HHP处理的BGC与未处理的BGC的力学性能并无差异，这与所施加的HHP大小和持续时间无关。我们的研究表明，HHP处理是同种异体骨替代材料当前加工技术的一种合适替代方法，因为它不会对力学性能产生负面影响。
