Department of Chemistry, Yunnan Normal University, Kunming, China.
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China.
Chirality. 2019 Dec;31(12):1053-1059. doi: 10.1002/chir.23134. Epub 2019 Oct 21.
Chiral mesoporous silica (CMS) has attracted widespread attention because of some unique properties, such as high surface area, uniformly structured nanoscale cavities, and excellent chemical and thermal stability. In this work, we report the utilization of a CMS as the stationary phase for the separation of racemates in gas chromatography (GC). A CMS-coated capillary column was fabricated by a dynamic coating method. Eighteen racemates belonging to different classes of organic compounds were separated on this column, including chiral alcohols, aldehydes, ketones, organic acids, halohydrocarbons, alkenes, alcohol amines, epoxides, and amino acid derivatives. In addition, linear alkanes, alcohols, and aromatic hydrocarbons have also been resolved.
手性介孔硅（CMS）因其具有一些独特的性质，如高比表面积、均匀的纳米级孔结构、以及良好的化学和热稳定性，而受到广泛关注。在这项工作中，我们报告了将 CMS 用作气相色谱（GC）中拆分外消旋体的固定相。通过动态涂覆法制备了 CMS 涂覆的毛细管柱。在该柱上分离了 18 种属于不同类有机化合物的外消旋体，包括手性醇、醛、酮、有机酸、卤代烃、烯烃、醇胺、环氧化物和氨基酸衍生物。此外，还拆分了线性烷烃、醇和芳烃。
