Khalil Zeyad, Alam Benyamin, Akbari Amir Reza, Sharma Harbans
Medical School, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Nutrients. 2021 Feb 21;13(2):691. doi: 10.3390/nu13020691.
Due to the potentially crucial role of vitamin K in calcium metabolism, a deficit can disrupt many mechanisms, resulting in an array of different issues, such as broken bones, stiff arteries and poor fertility. Although there has been existing research, the potential of vitamin K as a treatment for conditions including cerebral palsy, parathyroid disease, heart disease and gastrointestinal disease is unknown. This review discusses the biochemistry of vitamin K and the metabolism of calcium, followed by an analysis of the current literature available on vitamin K and its prospects.
Using public libraries including PubMed and Wiley, we searched for existing research on the metabolism and use of vitamin K that has been conducted in the preceding two decades.
Data indicated that vitamin K had a positive impact on osteoporosis, cardiovascular disease, parathyroid disorders, cerebral palsy and sperm motility.
Due to the existence of confounding variables and limitations in the quality and volume of research conducted, further investigation must be done to see whether the beneficial effects seen are reproducible and must assess the viability of vitamin K as treatment in isolation for these conditions.
由于维生素K在钙代谢中可能起着至关重要的作用,维生素K缺乏会破坏许多机制,导致一系列不同的问题,如骨折、动脉僵硬和生育能力低下。尽管已有相关研究,但维生素K作为治疗包括脑瘫、甲状旁腺疾病、心脏病和胃肠道疾病等病症的潜力尚不清楚。本综述讨论了维生素K的生物化学以及钙的代谢,随后分析了目前关于维生素K的现有文献及其前景。
我们利用包括PubMed和Wiley在内的公共数据库,搜索了过去二十年中关于维生素K代谢和用途的现有研究。
数据表明,维生素K对骨质疏松症、心血管疾病、甲状旁腺疾病、脑瘫和精子活力有积极影响。
由于存在混杂变量以及所开展研究的质量和数量存在局限性,必须进一步开展调查,以确定所观察到的有益效果是否具有可重复性,并且必须评估维生素K单独作为这些病症治疗方法的可行性。