胆囊切除术后患者饮食与胆固醇及色素性胆结石之间的关联：韩国的一项病例对照研究
Association between diet and gallstones of cholesterol and pigment among patients with cholecystectomy: a case-control study in Korea.
作者信息
Park Yongsoon, Kim Doyeon, Lee Ju Seon, Kim Yu Na, Jeong Yoon Kyung, Lee Kyeong Geun, Choi Dongho
机构信息
Department of Food and Nutrition, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, South Korea.
Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, South Korea.
出版信息
J Health Popul Nutr. 2017 Nov 23;36(1):39. doi: 10.1186/s41043-017-0116-y.
BACKGROUND
The prevalence of cholesterol gallstones is high in Western populations, while pigment gallstones are common in Asian populations. Dietary factors are suggested to be associated with gallstone risk, but their relationship with gallstone type has not been evaluated. This study investigated the association between diet and risk of cholesterol gallstone or pigment gallstone in a Korean population whose dietary pattern and type of gallstone were changed during the last 30 years.
METHODS
Patients with cholesterol (n = 40) and pigment (n = 59) gallstones were recruited after laparoscopic cholecystectomy and were compared with those of age- and sex-matched controls without gallstones (n = 99). Dietary intakes were assessed by trained dietitians using a semi-quantitative food frequency questionnaire. Multinomial logistic regression analysis was performed to calculate odds ratios and 95% confidence intervals to examine the associations between diet and risk for type of gallstones adjusted by potential confounders.
RESULTS
Patients with cholesterol gallstone consumed more lipid, animal lipid, beef, pork, and fried food than those with pigment gallstones and control, while patients with pigment gallstone consumed more carbohydrate and noodles than patients with cholesterol gallstone and control. In multinomial logistic regression analysis using control as reference group, dietary pattern with high consumption of beef, pork, and fried food was associated with risk of cholesterol gallstones, while there was no association between the risk of pigment gallstone and dietary pattern. In addition, control consumed more alcohol than patients with cholesterol and pigment gallstones.
CONCLUSIONS
The present study suggested consumption of fat from meat and fried foods increased the risk of cholesterol gallstone, and intake of carbohydrate from noodles increased the risk of pigment gallstone.
背景
胆固醇结石在西方人群中患病率较高，而色素结石在亚洲人群中较为常见。饮食因素被认为与胆结石风险有关，但其与胆结石类型的关系尚未得到评估。本研究调查了在过去30年中饮食模式和胆结石类型发生变化的韩国人群中，饮食与胆固醇结石或色素结石风险之间的关联。
方法
在腹腔镜胆囊切除术后招募胆固醇结石患者（n = 40）和色素结石患者（n = 59），并与年龄和性别匹配的无胆结石对照组（n = 99）进行比较。由训练有素的营养师使用半定量食物频率问卷评估饮食摄入量。进行多项逻辑回归分析以计算比值比和95%置信区间，以检验饮食与经潜在混杂因素调整后的胆结石类型风险之间的关联。
结果
胆固醇结石患者比色素结石患者和对照组摄入更多的脂质、动物脂质、牛肉、猪肉和油炸食品，而色素结石患者比胆固醇结石患者和对照组摄入更多的碳水化合物和面条。在以对照组作为参考组的多项逻辑回归分析中，高消费牛肉、猪肉和油炸食品的饮食模式与胆固醇结石风险相关，而色素结石风险与饮食模式之间无关联。此外，对照组比胆固醇结石和色素结石患者摄入更多酒精。
结论
本研究表明，食用肉类和油炸食品中的脂肪会增加胆固醇结石的风险，而摄入面条中的碳水化合物会增加色素结石的风险。
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