Department of Biology and Biomolecular Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada.
Molecules. 2021 Feb 18;26(4):1066. doi: 10.3390/molecules26041066.
is a medicinal plant native to Peru that has been traditionally used in the treatment of various inflammatory disorders. In this study, the effectiveness of as an anti-cancer agent was assessed using the growth and survival of B16-BL6 mouse melanoma cells. B16-BL6 cell cultures treated with both ethanol and phosphate-buffered saline (PBS) extracts of displayed up to 80% lower levels of growth and increased apoptosis compared to vehicle controls. Treatment with ethanolic extracts of were much more effective than treatment with aqueous extracts. was also shown to inhibit B16-BL6 cell growth in C57/bl mice in vivo. Mice injected with both the ethanolic and aqueous extracts of showed a 59 ± 13% decrease in B16-BL6 tumour weight and a 40 ± 9% decrease in tumour size. Histochemical analysis of the B16-BL6 tumours showed a strong reduction in the Ki-67 cell proliferation marker in -treated mice and a small, but insignificant increase in terminal transferase dUTP nick labelling (TUNEL) staining. Furthermore, extracts reduced angiogenic markers and reduced the infiltration of T cells into the tumours. Collectively, the results in this study concluded that has potent anti-cancer activity that significantly inhibited cancer cells in vitro and in vivo.
是一种原产于秘鲁的药用植物，传统上用于治疗各种炎症性疾病。在这项研究中，使用 B16-BL6 小鼠黑色素瘤细胞的生长和存活来评估 作为抗癌剂的效果。与载体对照相比，用 的乙醇和磷酸盐缓冲盐水 (PBS) 提取物处理的 B16-BL6 细胞培养物的生长水平降低了 80%以上，并且凋亡增加。用 的乙醇提取物处理比用水提取物处理更有效。还表明 在体内抑制 C57/bl 小鼠中的 B16-BL6 细胞生长。用 的乙醇和水提取物注射的小鼠的 B16-BL6 肿瘤重量减少了 59±13%，肿瘤大小减少了 40±9%。B16-BL6 肿瘤的组织化学分析显示，用 -处理的小鼠中 Ki-67 细胞增殖标志物的强烈减少，末端转移酶 dUTP 缺口标记 (TUNEL) 染色略有但无统计学意义的增加。此外，提取物降低了血管生成标志物并减少了 T 细胞浸润到肿瘤中。总的来说，这项研究的结果得出结论， 具有很强的抗癌活性，可显著抑制体外和体内的癌细胞。
