Faculty of Engineering in Foreign Languages, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Int J Mol Sci. 2021 Feb 18;22(4):2011. doi: 10.3390/ijms22042011.
Microfluidics is a relatively newly emerged field based on the combined principles of physics, chemistry, biology, fluid dynamics, microelectronics, and material science. Various materials can be processed into miniaturized chips containing channels and chambers in the microscale range. A diverse repertoire of methods can be chosen to manufacture such platforms of desired size, shape, and geometry. Whether they are used alone or in combination with other devices, microfluidic chips can be employed in nanoparticle preparation, drug encapsulation, delivery, and targeting, cell analysis, diagnosis, and cell culture. This paper presents microfluidic technology in terms of the available platform materials and fabrication techniques, also focusing on the biomedical applications of these remarkable devices.
微流控是一个相对新兴的领域，基于物理、化学、生物、流体动力学、微电子学和材料科学的综合原理。各种材料可以被加工成微型芯片，其中包含微尺度范围内的通道和腔室。可以选择多种方法来制造具有所需尺寸、形状和几何形状的此类平台。无论单独使用还是与其他设备结合使用，微流控芯片都可用于纳米颗粒的制备、药物包封、输送和靶向、细胞分析、诊断和细胞培养。本文从可用的平台材料和制造技术方面介绍了微流控技术，并重点介绍了这些出色设备在生物医学中的应用。
